Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction

“…19 Quercetin leads to apoptosis through DNA fragmentation, ROS production, alteration of the cell cycle, 20,21 It decreases the mobility and glycolysis of breast carcinoma cells by inactivating the AKT-mTOR signaling. 22 In addition, it was revealed in a previous study that pretreated-quercetin suppresses lipopolysaccharide-induced programmed cell death and osteoblast differentiation by regulating MAPK and Wnt/β-catenin signal transduction in mouse osteoblasts. 23 Moreover, quercetin induces the death of human endometrial cells through mitochondria membrane permeabilization, lipid peroxidation, MAPK and PI3K/AKT signal inactivation, and regulation of cyclin D1.…”

shRNA Glut-1 inhibits cell viability, apoptosis and migration of laryngeal carcinoma HEp-2 cells through regulating Beclin-1-mediated autophagy

“…Previous studies indicated that autophagy activation has a dual effect on the occurrence of tumors [37]. In most cases, it was shown that activated autophagy of cancer cells can induce autophagic cell death, which may represent a promising approach for cancer treatment [19][20][21][22][23][24][25][26][27][28][29][30][31]. In the present study, we showed that Glut-1 knockdown evoked autophagy activity in HEp-2 cells leading to subsequent cell apoptosis, suggesting that Glut-1 may be a novel inducer of cell autophagy and useful for the treatment of laryngeal carcinoma.…”

“…Preliminary studies have shown that autophagy through Glut-1 translocation affects glucose uptake of cancer cells [19][20][21][22][23]. In comparison with normal cells, cancer cells preferentially produce energy by glycolysis in anaerobic environments [4].…”

“…Autophagy through Glut-1 translocation has been shown to affect glucose uptake by cancer cells [19][20][21][22][23]. Autophagy is the process by which damaged proteins or organelles are degraded and recycled by eukaryotic cells, and it plays a dual role in promoting cell survival and inducing cell death during cancer growth and migration [19][20][21][22][23].…”

“…Autophagy through Glut-1 translocation has been shown to affect glucose uptake by cancer cells [19][20][21][22][23]. Autophagy is the process by which damaged proteins or organelles are degraded and recycled by eukaryotic cells, and it plays a dual role in promoting cell survival and inducing cell death during cancer growth and migration [19][20][21][22][23]. The energy supply of cancer cells in an anoxic environment is associated with high levels of Glut-1 expression and autophagy activation [24,25] suggesting that Glut-1-mediated energy supply and cell growth are involved in the process of autophagy.…”