Quercetin with the potential effect on allergic diseases

Jafarinia, Morteza; Hosseini, Mahnaz Sadat; Kasiri, Neda; Fazel, Niloofar; Fathi, Farshid; Ganjalikhani‐Hakemi, Mazdak; Eskandari, Nahid

doi:10.1186/s13223-020-00434-0

Cited by 121 publications

(93 citation statements)

References 49 publications

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“…Therefore, compounds that affect the function of keratinocytes will have therapeutic potential. Many studies have shown that natural ingredients, such as isoflavones, apigenin, quercetin, and chrysin, have very good pharmacological activities in this regard [ 9 , 10 , 11 , 12 , 13 , 14 ]. Neferine has been found to inhibit the production or release of inflammatory substances, cytokines, and chemokines in other tissues or cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Yang

Hung

et al. 2021

IJMS

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Atopic dermatitis (AD) is a chronic and persistent inflammatory skin disease characterized by eczematous lesions and itching, and it has become a serious health problem. However, the common clinical treatments provide limited relief and are accompanied by adverse effects. Therefore, there is a need to develop novel and effective therapies to treat AD. Neferine is a small molecule compound isolated from the green embryo of the mature seeds of lotus (Nelumbo nucifera). It has a bisbenzylisoquinoline alkaloid structure. Relevant studies have shown that neferine has many pharmacological and biological activities, including anti-inflammatory, anti-thrombotic, and anti-diabetic activities. However, there are very few studies on neferine in the skin, especially the related effects on inflammatory skin diseases. In this study, we proved that it has the potential to be used in the treatment of atopic dermatitis. Through in vitro studies, we found that neferine inhibited the expression of cytokines and chemokines in TNF-α/IFN-γ-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-κB signaling pathway. Through in vivo experiments, we used 2,4-dinitrochlorobenzene (DNCB) to induce atopic dermatitis-like skin inflammation in a mouse model. Our results show that neferine significantly decreased the skin barrier damage, scratching responses, and epidermal hyperplasia induced by DNCB. It significantly decreased transepidermal water loss (TEWL), erythema, blood flow, and ear thickness and increased surface skin hydration. Moreover, it also inhibited the expression of cytokines and the activation of signaling pathways. These results indicate that neferine has good potential as an alternative medicine for the treatment of atopic dermatitis or other skin-related inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Yang

Hung

et al. 2021

IJMS

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“…It has also been reported that quercetin inhibits the secretion of harmful chemical mediators, including histamine, leukotrienes, major basic protein, and eosinophil cationic protein from mast cells and eosinophils in vitro and in vivo [ 14 , 15 ]. Furthermore, the influence of quercetin on the production of T-cell cytokines was investigated using an asthmatic mouse model, and it was reported that quercetin could reduce the increased levels of IL-4, and increased IFN-γ levels in bronchoalveolar lavage fluid after antigenic challenge via the modulation of T-box protein expressed in T cells (T-bet) and GATA-3 gene expression, resulting in significant attenuation of all asthmatic reactions [ 16 , 17 ]. Although these reports strongly suggest that quercetin is a good candidate as a supplement for modulation of allergic diseases, including AR, the mechanisms of the therapeutic action of quercetin on allergic responses is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Th1/Th2 Cytokine Balance by Quercetin In Vitro

et al. 2020

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Background: Allergic rhinitis (AR) is well known to be an IgE-mediated chronic inflammatory disease in the nasal wall, which is primarily mediated by Th2-type cytokines such as IL-4, IL-5, and IL-13. Although quercetin is also accepted to attenuate the development of allergic diseases such as AR, the influence of quercetin on Th2-type cytokine production is not well understood. The present study was designed to examine whether quercetin could attenuate the development of AR via the modulation of Th2-type cytokine production using an in vitro cell culture technique. Methods: Human peripheral-blood CD4+ T cells (1 × 106 cells/mL) were cultured with 10.0 ng/mL IL-4 in the presence or absence of quercetin. The levels of IL-5, IL-13, and INF-γ in 24 h culture supernatants were examined by ELISA. The influence of quercetin on the phosphorylation of transcription factors NF-κB and STAT6, and mRNA expression for cytokines were also examined by ELISA and RT-PCR, respectively. Results: Treatment of cells with quercetin at more than 5.0 μM inhibited the production of IL-5 and IL-13 from CD4+ T cells induced by IL-4 stimulation through the suppression of transcription factor activation and cytokine mRNA expression. On the other hand, quercetin at more than 5.0 μM abrogated the inhibitory action of IL-4 on INF-γ production from CD4+ T cells in vitro. Conclusions: The immunomodulatory effects of quercetin, especially on cytokine production, may be responsible, in part, for the mode of therapeutic action of quercetin on allergic diseases, including AR.

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“…Pharmaceutical companies are involved in manufacturing supplements purported for use in asthma such as quercetin and pycnogenol [93]. Quercetin is one of the most natural polyphenolic antioxidants found in many food products, which exerts anti-allergic effects by suppressing airway hyperresponsiveness and eosinophil chemoattractants induced by periostin, leading to reduced risk of asthma and allergic diseases [94]. Pycnogenol (French Pinus pinaster) is a natural plant extract contains polyphenolic compounds capable of reducing asthma by inhibiting pro-inflammatory cytokine production [95].…”

Section: Data Applications and Influencesmentioning

confidence: 99%

Supplements for Smoking-Related Lung Diseases

Alsharairi¹

2021

Encyclopedia

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Supplements for smoking-related lung diseases are considered as nonfood products and thought to improve health. Multivitamins and antioxidants are the most commonly dietary supplements used by cancer and asthma patients. There are currently no clear regulatory guidelines that include dietary supplements and their effect on lung cancer and asthma patients, particularly in smokers. Several countries have taken steps to overcome challenges in regulating dietary supplements in the marketplace. These challenges include inadequate assurance of safety/efficacy, inaccuracy of product labeling, misleading health claims, and lack of analytical techniques for dietary supplements. There is a need to establish standards and regulation of dietary supplement use in patients with lung cancer and asthma. The aim of this entry is to expand knowledge on dietary supplements use and smoking-related lung diseases (lung cancer and asthma).

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Quercetin with the potential effect on allergic diseases

Cited by 121 publications

References 49 publications

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

Modulation of Th1/Th2 Cytokine Balance by Quercetin In Vitro

Supplements for Smoking-Related Lung Diseases

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