2018
DOI: 10.1136/archdischild-2017-314505
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Question 1: Is it safe to use ivermectin in children less than five years of age and weighing less than 15 kg?

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Cited by 44 publications
(28 citation statements)
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“…Of the other two patients, one received an additional dose of ivermectin, while the other required local application of benzyl benzoate . In the nine studies included in the literature review, ivermectin was administered for several indications, with resolution of clinical symptoms achieved in the majority of children ( n = 48/60; 80%), consistent with the efficacy data obtained from our study . The received dose was highly variable in our study (94–556 μg kg –1 ), probably because there is no suitable formulation for small children, and the physician had to use the 3‐mg tablets available.…”
Section: Discussionsupporting
confidence: 81%
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“…Of the other two patients, one received an additional dose of ivermectin, while the other required local application of benzyl benzoate . In the nine studies included in the literature review, ivermectin was administered for several indications, with resolution of clinical symptoms achieved in the majority of children ( n = 48/60; 80%), consistent with the efficacy data obtained from our study . The received dose was highly variable in our study (94–556 μg kg –1 ), probably because there is no suitable formulation for small children, and the physician had to use the 3‐mg tablets available.…”
Section: Discussionsupporting
confidence: 81%
“…8 In the nine studies included in the literature review, ivermectin was administered for several indications, with resolution of clinical symptoms achieved in the majority of children (n = 48/60; 80%), consistent with the efficacy data obtained from our study. 9 The received dose was highly variable in our study (94-556 lg kg -1 ), probably because there is no suitable formulation for small children, and the physician had to use the 3-mg tablets available. However, our study pointed out that the dosage must be sufficient, where administration of a low dose as a precaution in an infant risks a lack of efficacy.…”
Section: Discussionmentioning
confidence: 82%
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“…In the targeted elimination scenario, systemic insecticide safety restrictions can more than double the systemic insecticide duration necessary to achieve elimination. Prior to approval for new long-lasting systemic insecticides in children and pregnant women, these groups could instead receive regular dose ivermectin [35].…”
Section: Discussionmentioning
confidence: 99%