QUESTION 1: Teething issues: can doxycycline be safely used in young children?

Boast, Alison; Curtis, Nigel; Gwee, Amanda

doi:10.1136/archdischild-2016-310964

Cited by 11 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is probably due to the presence of tetracycline, which gives such coloration to the CTZ paste. The liberation of pigments by CTZ in aqueous medium may strengthen the theory described in the literature that the material represents a risk factor for color change in the successor permanent teeth, causing yellowish or brownish spots, due to the impregnation of tetracycline with dental tissues [30]. However, there is no evidence about this effect, and the occurrence of defects in the enamel of permanent teeth seems to be more related to the inflammatory process in the periapical region of deciduous tooth, due to the carious process [31,32].…”

Section: Discussionsupporting

confidence: 69%

Antibacterial and Solubility Analysis of Experimental Phytotherapeutic Paste for Endodontic Treatment of Primary Teeth

Freire

Sousa

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 69%

Antibacterial and Solubility Analysis of Experimental Phytotherapeutic Paste for Endodontic Treatment of Primary Teeth

Freire

Sousa

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

View full text Add to dashboard Cite

“…TC has been used since 1953, but in the early 1960s, dental side effects were associated with the use of TC. Children with cystic fibrosis who were treated with TC presented a high prevalence (23%–92%) of tooth discoloration in a dose- and age-dependent manner [25-28].…”

Section: Benefits and Risks Of Alternative Antimicrobialsmentioning

confidence: 99%

Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children

Yang

2019

Korean J Pediatr

View full text Add to dashboard Cite

Although Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, the emergence of macrolide-resistant MPP (MRMP) has made its treatment challenging. MRMP rapidly spread after the 2000s, especially in East Asia. MRMP is more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treating M. pneumoniae infections in children. MRMP is unlikely to be related to clinical, laboratory, or radiological severity, although it likely prolongs the persistence of symptoms and the length of hospital stay. Thereby, it causes an increased burden of the disease and poor quality of life for the patient as well as a societal socioeconomic burden. To date, the only alternative treatments for MRMP are secondary antimicrobials such as tetracyclines (TCs) or fluoroquinolones (FQs) or systemic corticosteroids; however, the former are contraindicated in children because of concerns about potential adverse events (i.e., tooth discoloration or tendinopathy). A few guidelines recommended TCs or FQs as the second-line drug of choice for treating MRMP. However, there have been no evidence-based guidelines. Furthermore, safety issues have not yet been resolved. Therefore, this article aimed to review the benefits and risks of therapeutic alternatives for treating MRMP in children and review the recommendations of international or regional guidelines and specific considerations for their practical application.

show abstract

“… 44 There is grade B evidence for lack of dental staining in children given short-course doxycycline, as may be given in scrub typhus. 148 – 151 Moreover, doxycycline reaches good concentrations in cerebrospinal fluid, as does minocycline, though use of the latter is limited by dose-related vestibular side effects. 151 Fluoroquinolones are not good drugs for treatment, 150 , 152 nor are penicillins, clarithromycin, and cephalosporins.…”

Section: Management Challengesmentioning

confidence: 99%

“… 157 The aim of therapy is to save both mother and child, 158 and the benefits of therapy with doxycycline outweigh the risks. 148 – 151 Cross et al opined that doxycycline treatment should be used in children and pregnant women for treating scrub typhus, as the infection-associated risks are too large and thus overwhelmingly against avoiding therapy with this agent. 151 Recently, Jang et al reported that intravenous azithromycin was efficacious in the treatment of severe scrub typhus.…”

Section: Management Challengesmentioning

confidence: 99%

Scrub typhus: risks, diagnostic issues, and management challenges

Prakash¹

2017

RRTM

View full text Add to dashboard Cite

Scrub typhus is an acute febrile illness in the “tsutsugamushi triangle”, transmitted by chiggers that can be treated effectively if detected early. Laboratory testing, including molecular and serological assays, is needed for confirming the diagnosis, especially in the absence of the pathognomonic eschar. In this review, factors that play a role in disease occurrence and clinical clues for diagnosis, in addition to risk factors contributing to disease severity, including mortality, are discussed in detail. Moreover, issues related to diagnostic assays, treatment, and mixed infections are also enumerated and described.

show abstract

QUESTION 1: Teething issues: can doxycycline be safely used in young children?

Cited by 11 publications

References 5 publications

Antibacterial and Solubility Analysis of Experimental Phytotherapeutic Paste for Endodontic Treatment of Primary Teeth

Antibacterial and Solubility Analysis of Experimental Phytotherapeutic Paste for Endodontic Treatment of Primary Teeth

Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children

Scrub typhus: risks, diagnostic issues, and management challenges

Contact Info

Product

Resources

About