Questionnaire‐based diagnosis of REM sleep behavior disorder in Parkinson's disease

Chahine, Lana M.; Daley, Joseph T.; Horn, Stacy; Colcher, Amy; Hurtig, Howard I.; Cantor, Charles R.; Dahodwala, Nabila

doi:10.1002/mds.25438

Cited by 54 publications

(35 citation statements)

References 20 publications

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“…In order to increase the sensitivity of the clinical diagnosis, two different screening tools were used to detect the presence of symptoms of RBD, namely the recently published RBD1Q20 and the RBDSQ 21. The latter has shown fair internal consistency in patients with PD and a good validity for the screening of RBD in this population, with a recommended cut-off of six points22 Indeed, its sensitivity in patients with PD, when compared to the diagnosis made according to ICDS-II criteria, ranges from 74% to 84%, while its specificity ranges from 63% to 96% in two different studies 22 41. Sensitivity and specificity of RBD1Q, however, have not been formally assessed in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder

Fantini

Macedo

Zibetti

et al. 2014

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder

Fantini

Macedo

Zibetti

et al. 2014

Journal of Neurology, Neurosurgery & Psychiatry

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“…We used the Constipation Module and calculated both the total score and the isolated sum of the constipation items (questions 9–14) [2, 22]. We investigated sleeping habits using the REM sleep behavior disorder screening questionnaire (RBDSQ) [23]. Salivary symptoms were evaluated using the Drooling Rating Scale (DRS) [24].…”

Section: Methodsmentioning

confidence: 99%

Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction

Fedorova

Knudsen

Mouridsen

et al. 2015

Parkinson's Disease

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Introduction. Decreased salivary flow and xerostomia are frequent findings in Parkinson's disease (PD), possibly caused by alterations in the parasympathetic tonus. Here we explore salivary acetylcholinesterase (AChE) activity as a potential biomarker in PD. Methods. We measured salivary flow, AChE activity, and total protein concentration in 30 PD patients and 49 healthy controls. We also performed exploratory correlation analyses with disease duration, motor symptom severity, autonomic complaints, and other nonmotor symptoms. Results. PD patients displayed significantly decreased salivary flow rate, significantly increased salivary AChE activity, and total protein concentration. Importantly, the AChE activity/total protein ratio was significantly increased in PD patients, suggesting that increased AChE activity cannot be explained solely by upconcentration of saliva. The Unified PD Rating Scale (UPDRS) score displayed significant correlation with total salivary protein (P = 0.002) and near-significant correlation with salivary flow (P = 0.07). Color vision test scores were also significantly correlated with AChE activity (P = 0.04) and total protein levels (P = 0.002). Conclusion. Salivary AChE activity is increased in PD patients compared to healthy controls. Future studies are needed to elucidate whether this parameter reflects the extent of neuronal damage and parasympathetic denervation in the salivary glands of PD patients.

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“…A cut-off score of 5 was reported by the authors as most useful when differentiating patients with idiopathic RBD from controls 12. As this cut-off is only associated with a specificity of 0.56,12 sensitivity analyses were also performed using a RBDSQ cut-off of 6 and 7, in the light of subsequent validation studies that found stronger test performance characteristics using these higher cut-offs 13 14…”

Section: Methodsmentioning

confidence: 99%

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

Rolinski

Szewczyk-Królikowski

Tomlinson

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

157

109

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BackgroundConcomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.MethodsThe study evaluated 475 patients with PD within 3.5 years of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes, controlling for confounding factors.ResultsThe overall frequency of pRBD was 47.2% (95% CI 42.7% to 51.9%). None of the patients had a previous diagnosis of RBD. Patients with PD and concomitant pRBD did not differ on motor phenotype and scored comparably on the objective motor scales, but reported problems with motor aspects of daily living more frequently. Adjusted for age, sex, disease duration and smoking history, pRBD was associated with greater sleepiness (p=0.001), depression (p=0.001) and cognitive impairment (p=0.006).ConclusionspRBD is common and under-recognised in early PD. It is associated with increased severity and frequency of non-motor features, poorer subjective motor performance and a greater impact on health-related quality of life.

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Questionnaire‐based diagnosis of REM sleep behavior disorder in Parkinson's disease

Abstract: A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.

Cited by 54 publications

References 20 publications

Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder

Increased risk of impulse control symptoms in Parkinson's disease with REM sleep behaviour disorder

Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

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