Questionnaires Assessing the Quality of Life of Ocular Allergy Patients

Mikhail, Ereeny; Azizoglu, Serap; Gokhale, Moneisha; Suphioglu, Cenk

doi:10.1016/j.jaip.2020.04.023

Cited by 15 publications

(18 citation statements)

References 28 publications

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“…Other factors relating to day-to-day habits and lifestyle, such as ability to play outdoors, swim, socialise, work and exercise, were reportedly also negatively impacted by symptoms of ocular allergy such as itching, redness and irritation [ 10 , 11 ]. In order to reduce the effects of ocular allergy on quality of life for the large number of sufferers globally, it is imperative that accurate diagnostic and treatment protocols are developed urgently [ 7 , 12 ]. An approach utilising the detection of ocular surface biomarkers in human tears associated with ocular allergy sufferers may serve as a viable diagnostic testing method, thereby preventing long-term changes and detrimental outcomes to the cornea and ocular surface in ocular allergy sufferers.…”

Section: Ocular Allergy Overviewmentioning

confidence: 99%

A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy

Aydin

Dhar

Gokhale

et al. 2022

Biology

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Ocular allergy is an immunoglobulin E-mediated Type I hypersensitivity reaction localised to the ocular surface and surrounding tissues. Primary signs and symptoms of ocular allergy include itching, redness, irritation and inflammation. Eye-rubbing caused by itching has been shown to alter ocular surface protein concentrations in conditions linked to ocular allergy such as keratoconus. In keratoconus, the cornea begins to thin and sag over time, leading to progressive vision loss and blindness in severe conditions. Due to the high incidence of ocular allergy sufferers rubbing their eyes in response to symptoms of itching, the protein landscape of the ocular surface may be significantly altered. Differential protein expression caused by long-term inflammation and eye-rubbing may lead to subsequent changes in ocular surface structure and function over time. This review aims to summarise and explore the findings of current ocular allergy proteome research conducted using techniques such as gel electrophoresis, mass spectrometry and lab-on-a-chip proteomics. Proteins of interest for this review include differentially expressed immunoglobulins, mucins, functional proteins, enzymes and proteins with previously uncharacterised roles in ocular allergy. Additionally, potential applications of this research are addressed in terms of diagnostics, drug development and future research prospects.

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Section: Ocular Allergy Overviewmentioning

confidence: 99%

A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy

Aydin

Dhar

Gokhale

et al. 2022

Biology

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“…As the conjunctiva covers most of the ocular surface area, conjunctival disorders can severely affect the quality of life [ 86 , 87 , 88 ]. Therapies based on reconstruction of the conjunctiva using 3D cell culture techniques, with conjunctival cells expanded in vitro on suitable matrices, are gaining increasing attention.…”

Section: Development Of 3d Cell Culture Modelsmentioning

confidence: 99%

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

Aydin

Dietrich

Witt

et al. 2021

IJMS

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There is a lack of knowledge regarding the connection between the ocular and nasal epithelia. This narrative review focuses on conjunctival, corneal, ultrastructural corneal stroma, and nasal epithelia as well as an introduction into their interconnections. We describe in detail the morphology and physiology of the ocular surface, the nasolacrimal ducts, and the nasal cavity. This knowledge provides a basis for functional studies and the development of relevant cell culture models that can be used to investigate the pathogenesis of diseases related to these complex structures. Moreover, we also provide a state-of-the-art overview regarding the development of 3D culture models, which allow for addressing research questions in models resembling the in vivo situation. In particular, we give an overview of the current developments of corneal 3D and organoid models, as well as 3D cell culture models of epithelia with goblet cells (conjunctiva and nasal cavity). The benefits and shortcomings of these cell culture models are discussed. As examples for pathogens related to ocular and nasal epithelia, we discuss infections caused by adenovirus and measles virus. In addition to pathogens, also external triggers such as allergens can cause rhinoconjunctivitis. These diseases exemplify the interconnections between the ocular surface and nasal epithelia in a molecular and clinical context. With a final translational section on optical coherence tomography (OCT), we provide an overview about the applicability of this technique in basic research and clinical ophthalmology. The techniques presented herein will be instrumental in further elucidating the functional interrelations and crosstalk between ocular and nasal epithelia.

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“…The researchers condensed the areas of life identified by patients as most important into 28 items; included were three ‘patient-specific’ questions asking individuals to report the three activities most impacted by their symptoms during the previous week. These questions were found to improve validity, adjust for cultural differences, and made the questionnaire more applicable in a clinical setting [13 ▪▪ ].…”

Section: Quality Of Life In Adults With Allergic Rhinoconjunctivitismentioning

confidence: 99%

“…Several studies have documented QoL for adolescents with allergic rhinitis or ARC, all of which demonstrate reduction in QoL compared with controls regardless of the instrument used [Kindliche Lebensqualität-Revised, Pediatric Quality of Life Inventory (PedsQL), Rhinoconjunctivitis Quality of Life Questionnaire, and Adolescent Rhinoconjunctivitis Quality of Life Questionnaire] [25]. In a study among Thai adolescents using the PedsQL, it was found that individuals with comorbid asthma demonstrated a poorer QoL, particularly in the arena of emotional functioning, than individuals with ARC alone [13 ▪▪ ,26]. Another study found Spanish adolescents identified failure to achieve academic goals and maintain positive familial relationships as aspects of life most affected by allergic rhinitis/ARC [13 ▪▪ ,27].…”

Section: Quality Of Life In Adolescents With Allergic Rhinoconjunctiv...mentioning

confidence: 99%

“…In a study among Thai adolescents using the PedsQL, it was found that individuals with comorbid asthma demonstrated a poorer QoL, particularly in the arena of emotional functioning, than individuals with ARC alone [13 ▪▪ ,26]. Another study found Spanish adolescents identified failure to achieve academic goals and maintain positive familial relationships as aspects of life most affected by allergic rhinitis/ARC [13 ▪▪ ,27]. A prospective study of Spanish adolescents that required participants to receive treatment with intranasal corticosteroids and oral antihistamines before entering the study found adolescents identified as ‘nonresponders’ to pharmacological intervention reported poorer QoL than those adolescents that responded to the treatments [13 ▪▪ ,28].…”

Section: Quality Of Life In Adolescents With Allergic Rhinoconjunctiv...mentioning

confidence: 99%

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Psychosocial impact of ocular surface allergic inflammatory disorders

Mendelson¹,

Quintanilla²,

Norris

et al. 2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAllergic rhinoconjunctivitis is one of the most common ocular surface allergic inflammatory conditions seen in primary care that impacts patient's quality of life. Allergic conjunctivitis is increasingly being recognized as its own symptom complex that negatively impacts patient's quality of life separate from allergic rhinitis. This article reviews the psychosocial impact of ocular surface allergic inflammatory disorders (namely seasonal allergic conjunctivitis, ocular allergy, perennial allergic conjunctivitis, and atopic keratoconjunctivitis) on adult and pediatric populations.Recent findingsDespite the perception that allergic conjunctivitis is a trivial condition, it imposes a burden on numerous psychosocial aspects of life for adolescents and adults. Several questionnaires specific to rhinoconjunctivitis have been found to be effective tools at gauging quality of life (QoL) and communicating impairments in specific behavioral domains for adult and pediatric populations. An emerging focus on the role of hormone fluctuations and age on ocular surface allergic inflammation underscores the importance of nuancing the physiologic effects on ocular allergy and QoL at every decade of life.SummaryFurther exploration and research of symptoms by age would greatly improve our understanding of age's impact on QoL in these patients and contribute to improved management of allergic conjunctivitis.

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Questionnaires Assessing the Quality of Life of Ocular Allergy Patients

Cited by 15 publications

References 28 publications

A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy

A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

Psychosocial impact of ocular surface allergic inflammatory disorders

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