Questionnaires for measuring fatigue and its impact on health perception in inflammatory bowel disease

Castillo-Cejas, María Dolores; Robles, Virginia; Borruel, Natalia; Torrejón, Antonio; Navarro, Ester Marco; Peláez, Andrés; Casellas, Francesc

doi:10.4321/s1130-01082013000300005

Cited by 18 publications

(10 citation statements)

References 43 publications

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“…20 Also the Fatigue Impact scale (FIS, 40 items), with particular reference to the cognitive fatigue dimension in this study (10 items), was applied as in multiple studies previously in IBD. 5,21 The FIS asks the participant to rate his or her fatigue in the past month in reference to each item’s statement on a scale of 0 (no problem) to 4 (extreme problem). The cognitive fatigue subscore of the FIS has a maximum possible score of 40, indicating severe cognitive fatigue.…”

Section: Methodsmentioning

confidence: 99%

Cognitive impairment in Crohn’s disease is associated with systemic inflammation, symptom burden and sleep disturbance

2017

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Background: Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. Objective: The objective of this article is to objectively measure cognitive impairments in patients with CD compared with healthy controls, and if present, to identify potentially modifiable, contributing factors associated with cognitive impairment. Methods: CD patients and healthy age-/sex-matched controls completed surveys encompassing clinical, demographic, psychiatric, fatigue and sleep parameters. Contemporaneously, disease activity assessment with serum CRP, faecal calprotectin, Harvey-Bradshaw Index and the Subtle Cognitive Impairment test (SCIT) were performed, with the primary measure of response time (SCIT-RT) compared between groups. Multiple linear regression assessed for factors associated with slower SCIT-RT, denoting subtle cognitive impairment. Results: A total of 49 CD and 31 control individuals participated, with median age 44 years (range 22-65) and 43 years (21-63), respectively. Compared to controls, SCIT-RT was slower across all timepoints in CD patients (ANOVA p < 0.001). In multivariate analysis, serum CRP (standardised beta coefficient 0.27, 95% CI (0.02, 0.51)), abdominal pain (0.43 (0.16, 0.70)), plasma haemoglobin (1.55 (1.42, 1.68)), and concurrent fatigue (0.56 (0.25, 0.88)) were each independently associated with slower SCIT-RT in CD (each p < 0.05), with a trend for poorer sleep quality 0.54 (À0.03, 1.11) (p ¼ 0.06), yet conversely, higher faecal calprotectin titres were associated with faster SCIT-RT (À1.77 (À1.79, À1.76), p < 0.01).Conclusions: Patients with CD demonstrated subtle cognitive impairment utilising the objective SCIT, correlating with systemic inflammation and other disease burden measures, although higher faecal calprotectin titres were unexpectedly associated with less cognitive impairment.

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Section: Methodsmentioning

confidence: 99%

Cognitive impairment in Crohn’s disease is associated with systemic inflammation, symptom burden and sleep disturbance

2017

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“…22 It has been adequately translated and validated to Spanish and correlates with clinical activity and the IBDQ-36 in patients with IBD. 23 …”

Section: Assessment Of Fatiguementioning

confidence: 97%

Iron Deficiency in the Absence of Anemia Impairs the Perception of Health-Related Quality of Life of Patients with Inflammatory Bowel Disease

Herrera-deGuise

Casellas

Robles

et al. 2016

Inflammatory Bowel Diseases

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“…A recent review of the literature by Czuber-Dochan et al (14) , regarding fatigue in IBD patients, identified that fatigue prevalence ranges from 22% to 41% when the disease is in remission, to 86% when it is active. Fatigue may lead to considerable impairment in the patient's daily life and three studies demonstrated that it is associated with reduced HRQOL (12,22,38) . Therefore, easily reversible causes of fatigue should be identified and treated to prevent unnecessary patients' distress and suffering, and before more time and resource consuming investigations are undertaken.…”

Section: Discussionmentioning

confidence: 99%

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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-Context -Inflammatory bowel disease causes physical and psychosocial consequences that can affect the health related quality of life. Objectives -To analyze the relationship between clinical and sociodemographic factors and quality of life in inflammatory bowel disease patients. Methods -Ninety two patients with Crohn's disease and 58 with ulcerative colitis, filled in the inflammatory bowel disease questionnaire (IBDQ-32) and a questionnaire to collect sociodemographic and clinical data. The association between categorical variables and IBDQ-32 scores was determined using Student t test. Factors statistically significant in the univariate analysis were included in a multivariate regression model. Results -IBDQ-32 scores were significantly lower in female patients (P<0.001), patients with an individual perception of a lower co-workers support (P<0.001) and career fulfillment (P<0.001), patients requiring psychological support (P = 0.010) and pharmacological treatment for anxiety or depression (P = 0.002). A multivariate regression analysis identified as predictors of impaired HRQOL the female gender (P<0.001) and the perception of a lower co-workers support (P = 0.025) and career fulfillment (P = 0.001). Conclusion -The decrease in HRQQL was significantly related with female gender and personal perception of disease impact in success and social relations. These factors deserve a special attention, so timely measures can be implemented to improve the quality of life of patients. HEADINGS -Inflammatory bowel diseases. Crohn disease. Ulcerative colitis. Quality of life. Questionnaires.

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Questionnaires for measuring fatigue and its impact on health perception in inflammatory bowel disease

Abstract: in inflammatory bowel disease, fatigue measurement questionnaires have good properties and show that fatigue is an important manifestation of the disease, which has a significant impact on quality of life of patients.

Cited by 18 publications

References 43 publications

Cognitive impairment in Crohn’s disease is associated with systemic inflammation, symptom burden and sleep disturbance

Cognitive impairment in Crohn’s disease is associated with systemic inflammation, symptom burden and sleep disturbance

Iron Deficiency in the Absence of Anemia Impairs the Perception of Health-Related Quality of Life of Patients with Inflammatory Bowel Disease

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

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