Questions around <i>Encephalitozoon cuniculi</i> in rabbits

Varga, Molly

doi:10.1136/vr.g2494

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Serological check of rabbits is recommended, considered that E. cuniculi infection suppresses both humoral and cell-mediated immunity [29], making seropositive animals more likely to become unwell from any supervening pathological cause. Furthermore, such routine screening tests would reduce the diffusion of this potential zoonotic microorganism allow the establishment of E. cuniculi-free colonies [30].…”

Section: Discussionmentioning

confidence: 99%

Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings

Maestrini

Ricci

Cantile

et al. 2017

Comparative Immunology, Microbiology and Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings

Maestrini

Ricci

Cantile

et al. 2017

Comparative Immunology, Microbiology and Infectious Diseases

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“…It represents a major health issue for rabbits in which seroprevalence rates have been estimated by 37–68% of the pet population [24]. Although it has been largely studied for pathophysiology and immunology in experimental rodent models [9,10] and, to a limited point, in some experimentally-infected rabbits [8,25], additional insights are needed in naturally-infected hosts [26]. In the current study, we applied new mass spectrometry (MS) tools to comprehensively explore proteomic changes during E .…”

Section: Discussionmentioning

confidence: 99%

Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits

et al. 2017

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Encephalitozoon cuniculi is a microsporidian species which can induce subclinical to serious disease in mammals including rabbits, a definitive natural host. The pathophysiology of infection has not been comprehensively elucidated. In this exploratory study, we utilized two mass spectrometry approaches: first, the analysis of the humoral response by profiling the microsporidian antigens as revealed by Western blot screening, and second, implementing the iTRAQ®-labeling protocol to focus on the changes within the host proteome during infection. Seven E. cuniculi proteins were identified at one-dimensional gel regions where specific seropositive reaction was observed by Western blot, including polar tube protein 3, polar tube protein 2, and for the first time reported: heat shock related 70kDa protein, polysaccharide deacetylase domain-containing protein, zinc finger protein, spore wall and anchoring disk complex protein EnP1, and translation elongation factor 1 alpha. In addition, there was a significant increase of nine host proteins in blood samples from E. cuniculi-diseased rabbits in comparison with non-diseased control subjects undergoing various inflammatory processes. This included serum paraoxonase, alpha-1-antiproteinase F precursor and alpha-1-antiproteinase S-1 which have presumptive catalytic activity likely related to infection control, and cystatin fetuin-B-type, an enzyme regulator that has been poorly studied to date. Notably, 11 proteins were found to be statistically increased in rabbits with neurological versus renal clinical presentation of E. cuniculi infection. Overall, this novel analysis based on mass spectrometry has provided new insights on the inflammatory and humoral responses during E. cuniculi infection in rabbits.

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“…Andere Schäden (z. B. Myokarditis, Hepatitis, Splenitis, Pneumonie, Aborte) fallen eher seltener auf [10], [26]. Nach einer aktuellen deutschen Studie [8] hatten 90 % (82/91) der Kaninchen mit bewiesener Enzephalitozoonose (Nachweis durch PCR und/oder Sektion) ZNS-Probleme (Vestibularsyndrom: 71 %, Paresen: 19 %); 29 % (26/91) Nieren-Probleme (Azotämie: 18 %, PD/PU: 12 %) und 12 % (11/91) Augen-Probleme.…”

Section: Znsunclassified

Alles Enzephalitozoonose – oder gibt es da noch mehr?

Hein

2015

kleintier konkret

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Immer wenn ein Kaninchen mit neurologischen St?rungen wie Vestibularsyndrom oder L?hmungen, Augenver?nderungen oder Niereninsuffizienz in der Praxis vorgestellt wird, ist man auch ohne Diagnostik oft schnell mit der Diagnose ?Enzephalitozoonose? bei der Hand. Aber ist die Enzephalitozoonose tats?chlich so h?ufig? Wie erfolgt die Diagnose? Welche Differenzialdiagnosen kommen infrage? Wie sollte die Therapie aussehen und wie ist die die Prognose?

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Questions around Encephalitozoon cuniculi in rabbits

Cited by 9 publications

References 11 publications

Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings

Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings

Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits

Alles Enzephalitozoonose – oder gibt es da noch mehr?

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