Quetiapine-Associated Myopericarditis

Bhogal, Sukhdeep; Ladia, Vatsal; Paul, Timir K.

doi:10.1097/mjt.0000000000000671

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…Non drug-related causes of myocarditis, such as viral infections, were less likely because of the lack of symptoms associated with viral disease and the arise of symptoms shortly after the initiation of clozapine. Besides clozapine, few cases have been described in which lamotrigine or quetiapine was the cause of drug-induced myocarditis [21][22][23][24]. However, our patient was using lamotrigine and quetiapine long before the symptoms occurred (> 1 year), making it far less likely to be the current cause of the myocarditis.…”

Section: Case Presentationmentioning

confidence: 73%

Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report

2020

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Background Clozapine is an atypical antipsychotic proven to be superior in the treatment of treatment-resistant schizophrenia. Myocarditis is a rare, but well-known complication of treatment with clozapine. Only few cases have been reported in which nausea and vomiting were prominent symptoms. This is the first described report in which nausea and vomiting were the only presenting symptoms of clozapine-induced myocarditis. Case presentation We report a case of a 58-year-old woman, suffering from schizoaffective disorder, who is being treated with clozapine. Two weeks after initiation of clozapine, she developed nausea and vomiting, in absence of any other clinical symptoms. Laboratory examination and magnetic resonance imaging confirmed the diagnosis of clozapine-induced myocarditis. Clozapine was discontinued and the patient recovered fully. Conclusions This case emphasizes the importance of recognizing myocarditis as a cause of isolated nausea and vomiting in patients treated with clozapine. Early recognition improves clinical outcome and reduces mortality.

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Section: Case Presentationmentioning

confidence: 73%

Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report

2020

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“…There are 2 case reports found on quetiapine associated with pericarditis/myopericarditis including the first highlighted case report 2,8 . The other case report discusses a patient who had quetiapine associated with myopericarditis 8 . The second and third case reports would suggest that aripiprazole could be a safe alternative atypical antipsychotic for patients who developed pericarditis while on clozapine, as these 2 patients did not have a recurrence of pericarditis when clozapine was discontinued and did not have pericarditis while on aripiprazole 5,6 .…”

Section: Discussionmentioning

confidence: 99%

“…2,8 The other case report discusses a patient who had quetiapine associated with myopericarditis. 8 The second and third case reports would suggest that aripiprazole could be a safe alternative atypical antipsychotic for patients who developed pericarditis while on clozapine, as these 2 patients did not have a recurrence of pericarditis when clozapine was discontinued and did not have pericarditis while on aripiprazole. 5,6 The first case report suggests that aripiprazole would be a safer alternative to quetiapine.…”

Section: Discussionmentioning

confidence: 99%

Pericarditis Associated With Aripiprazole

Onggo

Chang

Singh

et al. 2023

J Clin Psychopharmacol

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“…Quetiapine is a dibenzothiazepine derivative second generation antipsychotic agent. Clozapine, a structurally similar dibenzodiazepine derivative second-generation antipsychotic, is similar to quetiapine in terms of its mechanism of action and side effects, including cardiac adverse event 6,7 . It has been found that approximately 1-3% of patients treated with clozapine developed myocarditis 8,9 .…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are three cases of myocarditis associated with the use of quetiapine to date. In one of these cases, quetiapine was used alone, in the other cases combined with lithium or methylphenidate 4,5,7 . We present the second case of myocarditis related to quetiapine treatment alone.…”

Section: Discussionmentioning

confidence: 99%

Ketiapine Bağlı Myokardit

Gezer¹,

Kaçmaz

YURTSEVER

2022

Eurasian Journal of Toxicology

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Bu makale, ketiapin doz aşımına bağlı miyokarditi bildirmektedir. Anksiyete bozukluğu nedeniyle 25 mg ketiapin kullanan 18 yaşında kadın hasta, 20 adet ketiapin hapı ile intihar girişiminde bulundu. Acil serviste hastada çarpıntı, nefes darlığı, plöretik göğüs ağrısı ve konfüzyon gelişti. Hastanın EKG'sinde D1-aVL derivasyonlarında ST elevasyonu ve sağ dal bloğu saptandı. Kardiyak belirteçler önemli ölçüde yükseldi. Hasta dahiliye yoğun bakım ünitesinde tedavi altına alındı. İlaca bağlı miyokardit, iki haftalık tedaviyle düzeldi. Bu vaka raporu, ketiapin doz aşımının neden olduğu bir miyokardit vakasını sunmaktadır.

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Quetiapine-Associated Myopericarditis

Cited by 7 publications

References 7 publications

Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report

Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report

Pericarditis Associated With Aripiprazole

Ketiapine Bağlı Myokardit

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