Quetiapine Poisoning Associated With Neuroleptic Malignant Syndrome, Rhabdomyolysis and Renal Failure: A Case Report

Nincevic, Zeljko; Lasić, Davor; Glavina, Trpimir; Mikačić, Marijana; Carev, Mladen; Podrug, Kristijan

doi:10.24869/psyd.2017.84

Cited by 5 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were similar to the findings observed by Minns & Clark, (2012) and Borg et al (2016). Sinus tachycardia is mediated by muscarinic (M1), antihistaminic (H1) and α1 adrenoceptor antagonism properties of antipsychotics (Rasimas &Liebelt, 2012 andNincevic et al, 2017). However, prolonged QTc is caused by K channel antagonism (Tan et al, 2009).…”

Section: Discussionsupporting

confidence: 89%

ECG Changes as a Predictive Tool of Outcomes in Antipsychotics Poisoned Patients

El-Gharbawy

Ghonem

2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Background: Antipsychotics are a class of medications that are primarily used for treatment of psychosis especially schizophrenia. The most common cardio-toxic features of antipsychotics overdose are tachycardia, hypotension, and prolonged corrected QT interval. Aim: This study aimed at assessment of ECG changes utilization as a predictor of major outcome events in antipsychotic poisoned patients. Patients and methods: This prospective observational study was conducted at Tanta Poison Control Unit on 43 patients of both sexes with antipsychotics poisoning. For each patient, socio-demographic and toxicological data were collected, physical examination was performed, and routine investigations were measured. Electrocardiogram was done, and corrected QT was calculated. The severity of symptoms and signs of antipsychotics poisoning and related ECG changes were graded according to poisoning severity score. Results: This study revealed significant association between ECG grading and each of seizures, ICU admission, and in-hospital mortality. Significant association was also detected between corrected QT interval and ICU admission. Conclusion: It was concluded that, ECG changes could be used to predict mortality and major outcome events in antipsychotics intoxicated patients.

show abstract

Section: Discussionsupporting

confidence: 89%

ECG Changes as a Predictive Tool of Outcomes in Antipsychotics Poisoned Patients

El-Gharbawy

Ghonem

2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…Se debe tener presente, en el diagnóstico diferencial, principalmente la patología infecciosa que, incluso, podría desencadenar el síndrome neuroléptico maligno. Además, cabe precisar que el SNM abarca múltiples problemas como el estado severo de deshidratación, alteración hidroelectrolítica que conlleva a la injuria renal aguda (3,5) , y el caso de nuestro estudio no es la excepción.…”

Section: Discussionunclassified

Rigidez muscular, trastorno de sensorio y antipsicóticos: Reporte de caso

Ramos-Cabrera

Ramírez-Calderón

2019

HorizMed

View full text Add to dashboard Cite

En los servicios de emergencias que atienden a una gran población, muchas veces se encuentran cuadros aislados, como deshidratación severa, hipernatremia o hiponatremia, injuria renal aguda, trastorno de sensorio, entre otras. Sin embargo, muchos de estos cuadros forman parte de una sola patología, y si no se hace una unidad clínica en el momento adecuado, la morbimortalidad se puede incrementar drásticamente. Sobre todo, en enfermedades con baja frecuencia, muy raras o poco habituales, como la que se narrará a continuación, podría empeorar el estado crítico del paciente si no se detecta a tiempo o no se maneja adecuadamente. Este caso clínico es el de una paciente mujer de 74 años, con antecedente de patología psicótica con tratamiento irregular que, tras ingerir carbamazepina y risperidona, presenta los síntomas típicos y poco frecuentes del síndrome neuroléptico maligno (SNM).

show abstract

Alprazolam/quetiapine overdose

2017

Reactions Weekly

View full text Add to dashboard Cite

Quetiapine Poisoning Associated With Neuroleptic Malignant Syndrome, Rhabdomyolysis and Renal Failure: A Case Report

Cited by 5 publications

References 6 publications

ECG Changes as a Predictive Tool of Outcomes in Antipsychotics Poisoned Patients

ECG Changes as a Predictive Tool of Outcomes in Antipsychotics Poisoned Patients

Rigidez muscular, trastorno de sensorio y antipsicóticos: Reporte de caso

Alprazolam/quetiapine overdose

Contact Info

Product

Resources

About