Quick assessment of drug-related admissions over time (QUADRAT study)

Herwaarden, Margaretha F. Warlé-van; Valkhoff, Vera E.; Herings, Ron M. C.; Engelkes, Marjolein; Blijderveen, Jan C. van; Rodenburg, Eline M.; Bie, Sandra de; Alsma, Jelmer; Steeg-Gompel, Caroline van de; Kramers, Cornelis; Meyboom, R.H.B.; Sturkenboom, Miriam; Smet, Peter A. G. M. De

doi:10.1002/pds.3747

Cited by 13 publications

(23 citation statements)

References 17 publications

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“…The Quick Assessment of Drug-Related Admissions over Time (QUADRAT) study showed a decreasing trend of possible HARMs in The Netherlands between 2005 (4.65%) and 2008 (3.91%). 11 These results are comparable to findings in other Western countries. [13][14][15] The percentage of potentially preventable HARMs only showed a small decreasing trend in the QUADRAT study with 20.5% in 2005 and 18.4% in 2008.…”

Section: Introductionsupporting

confidence: 86%

“…The percentage of potentially preventable HARMs only showed a small decreasing trend in the QUADRAT study with 20.5% in 2005 and 18.4% in 2008 11 . This potential preventability was lower compared to the other Dutch studies which calculated a percentage of 29,0% and 46.0%.…”

Section: Introductionmentioning

confidence: 60%

“…Additionally checklists and toolkits were implemented and protocols and guidelines were drafted or revised. 18 These initiatives did not lead to significant improvements in the QUADRAT study, 11 but implementation of protocols and guidelines takes time and thus this study may have come too early. Therefore, a study was designed with the primary aim to determine whether these initiatives have led to a reduction in the prevalence and incidence rate of possible HARMs and potentially preventable HARMs in The Netherlands in the years 2008 to 2013.…”

Section: Introductionmentioning

confidence: 98%

“…In The Netherlands, one prospective and two retrospective studies have been performed to estimate the prevalence of possible HARMs in 2003HARMs in , 2005HARMs in , 2006 and 2008. [10][11][12] These studies have shown a prevalence of possible HARMs between 3.9 and 5.6% of acute admissions. The Quick Assessment of Drug-Related Admissions over Time (QUADRAT) study showed a decreasing trend of possible HARMs in The Netherlands between 2005 (4.65%) and 2008 (3.91%).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands

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Flinterman

et al. 2020

Pharmacoepidemiology and Drug

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In 2009 a Dutch guideline was published containing recommendations to reduce Hospital Admissions Related to Medications (HARMs). This study aims to examine time-trends of HARMs and their potential preventability between 2008 and 2013 in The Netherlands. Methods: A retrospective prevalence study was conducted using the Dutch PHARMO Database Network. A semi-automated pre-selection was used to make a crude identification of possible HARMs of which four samples were selected. These were independently assessed with respect to causality and potential preventability by a physician and pharmacist. The results were stratified by age into 18-64 years and 65 years and older. For these groups the net prevalences and incidence rates of HARMs and potentially preventable HARMs were calculated for the years

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Section: Introductionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands

Said

Hek

Flinterman

et al. 2020

Pharmacoepidemiology and Drug

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“…The Dutch guideline "Polypharmacy in the older patient" includes a trigger list that can be used to establish whether an admission is possibly medication related [62]. The trigger list is mainly based on three studies namely the HARM-, IPCI-and Quadret, and presents the most frequent medication related problems which can lead to an admission [7,11,63,64].…”

Section: Discussionmentioning

confidence: 99%

Medication-related hospital admissions and readmissions in older patients: an overview of literature

et al. 2020

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Background The number of medication related hospital admissions and readmissions are increasing over the years due to the ageing population. Medication related hospital admissions and readmissions lead to decreased quality of life and high healthcare costs. Aim of the review To assess what is currently known about medication related hospital admissions, medication related hospital readmissions, their risk factors, and possible interventions which reduce medication related hospital readmissions. Method We searched PubMed for articles about the topic medication related hospital admissions and readmissions. Overall 54 studies were selected for the overview of literature. Results Between the different selected studies there was much heterogeneity in definitions for medication related admission and readmissions, in study population and the way studies were performed. Multiple risk factors are found in the studies for example: polypharmacy, comorbidities, therapy non adherence, cognitive impairment, depending living situation, high risk medications and higher age. Different interventions are studied to reduce the number of medication related readmission, some of these interventions may reduce the readmissions like the participation of a pharmacist, education programmes and transition-of-care interventions and the use of digital assistance in the form of Clinical Decision Support Systems. However the methods and the results of these interventions show heterogeneity in the different researches. Conclusion There is much heterogeneity in incidence and definitions for both medication related hospital admissions and readmissions. Some risk factors are known for medication related admissions and readmissions such as polypharmacy, older age and additional diseases. Known interventions that could possibly lead to a decrease in medication related hospital readmissions are spare being the involvement of a pharmacist, education programs and transition-care interventions the most mentioned ones although controversial results have been reported. More research is needed to gather more information on this topic.

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Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission: a retrospective cohort study

et al. 2022

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Quick assessment of drug-related admissions over time (QUADRAT study)

Abstract: Automated pre-selection of PP-ADEs is an efficient way to monitor crude trends. Further validation and manual assessment of the automatically selected hospitalizations is necessary to get a more detailed and precise picture.

Cited by 13 publications

References 17 publications

Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands

Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands

Medication-related hospital admissions and readmissions in older patients: an overview of literature

Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission: a retrospective cohort study

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