Quick synthesis of fluorescent nitrogen-doped carbon nanoparticles for selective and sensitive Fe(III) detection in water

Molkenova, Anara; Amangeldinova, Yerkezhan; Aben, Dimaral; Sayatova, Saya; Atabaev, Timur Sh.

doi:10.1016/j.sbsr.2019.100271

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…The peaks at 1457 and 1352 cm −1 were associated with C=C and C−N stretching vibration ( Figure D ) . These results showed the presence of various functional groups like (‐OH, ‐NH 2 , and ‐C=O) . Addition to this, the zeta potential of the GB‐CDs was −20.26 mV (Supporting Information Figure S2 ).…”

Section: Resultsmentioning

confidence: 86%

“…These results showed the presence of various functional groups like (-OH, -NH 2 , and -C=O). [33,34,35] Addition to this, the zeta potential of the GB-CDs was À 20.26 mV (Supporting Information Figure S2). The occurrence of the different functional groups not only revealed the negative charge on GB-CDs surface but also advances their stability, electronic properties and hydrophilic character in aqueous systems.…”

Section: Characterizationsmentioning

confidence: 93%

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A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

et al. 2019

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Herein, a facile, green and eco‐friendly approach has been applied for the synthesis of fluorescent green‐blue carbon dots (GB‐CDs) through the one‐pot hydrothermal treatment of Artocarpus lakoocha seeds for the first time and entirely characterized via a variety of instrumental techniques like fluorescent spectroscopy, Transmission Electron Microscopy (TEM), X‐Ray Photoelectron Spectra (XPS), X‐Ray diffraction (XRD) and Fourier Transform Infra‐red (FTIR) analysis. The as‐prepared GB‐CDs displayed high fluorescent quantum yield (QY) up to 38.5% and high photostability based on which GB‐CDs were successfully applied as a sensitive nanoprobe for the detection of Fe3+ ion. The sensing of Fe3+ shows a linear range from 2 to 6 μM and the limit of detection was found to be 0.62 μM. The sensing of Fe3+ was further investigated in the bona fide sample like river water and human blood serum. In addition, to explore the potential application, MTT assay was carried out on SH‐SY5Y neuroblastoma cells. The results showed negligible cytotoxicity as well as high cell viability, which revealed that GB‐CDs could be utilized as a fluorescent probe in living cells.

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Section: Resultsmentioning

confidence: 86%

Section: Characterizationsmentioning

confidence: 93%

A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

et al. 2019

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“…Hence, CQDs with high QY, robust stability, and flexible synthesis procedures may provide unique advantages in the quantitative and qualitative detection of Fe 3+ ions. To date, many studies have been performed to detect Fe 3+ ions in biological samples using CQDs [50][51][52][53][54][55][56][57][58][59][60][61][62]. In addition to CQDs, other nanoparticle systems such as graphene QDs, inorganic QDs, MgO, and gold nanoparticles have been extensively employed in the detection of Fe 3+ ions [63][64][65][66][67][68][69].…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Synthesis of Nitrogen-Doped and Excitation-Dependent Carbon Quantum Dots for Selective Detection of Fe3+ in Blood Plasma

et al. 2022

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In the last two decades, fluorescent carbon quantum dots (CQDs) have attracted intense interest as a new fluorescent nanomaterial with unique properties. This material offers significant advantages compared with conventional dyes and inorganic QD systems, and is used extensively in many different fields, especially in bioimaging and sensor applications. Despite all the positive values they offer, the production of CQD systems with excitation wavelength-dependent nature and high quantum yield (QY) is still a scientific challenge. In this study, we proposed the fabrication of CQD through a facile and easy-to-tune hydrothermal method using cheap and biocompatible precursors such as urea and lactic acid. The effect of experimental parameters including synthesis time, temperature, and mass ratio of the precursors, were determined to obtain the highest QY (48%). The as-prepared nitrogen-doped (N-doped) CQDs exhibited robust stability in the dark and in a wide range of pH values with excitation wavelength-dependent properties. Additionally, CQDs showed remarkable sensitivity and selectivity in the sensing of Fe3+ in blood plasma with a linear correlation in the range of 0–1000 μM, indicating the high potential of CQDs in practical applications. Lastly, cytotoxicity and antibacterial activity tests demonstrated the low toxicity and high biocompatibility of proposed CQDs. Considering the facile and efficient synthetic method, easy-to-tune optical properties, excitation-dependent nature, high fluorescence activity, and low cytotoxicity, we strongly anticipate that N-doped CQDs could provide unique advantages in various biomedical applications including diagnosis, bioimaging, and biosensors.

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“…Iron, an indispensable trace element in living organisms, takes crucial part in many biochemical processes. , The mitochondrion is the only site where heme can be synthesized, while Fe 3+ is one of the most abundant metal ions in mitochondria . The dysregulation of mitochondrial Fe 3+ can cause diseases related to mitochondria such as Friedreich’s ataxia and iron–sulfur cluster deficiency .…”

Section: Introductionmentioning

confidence: 99%

Biomass-Based Carbon Dots for Fe³⁺ and Adenosine Triphosphate Detection in Mitochondria

Durrani

Zhang

Mukramin

et al. 2022

ACS Appl. Nano Mater.

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Real-time live-cell monitoring of Fe3+ and adenosine triphosphate (ATP) in mitochondria important for cellular functions and related to different diseases is highly desired, yet lack study. Herein, carbon dots, green bean (GB)-carbon dots (CDs), were made from GB through easy one-step hydrothermal treatment. GB-CDs were in spherical form with a diameter of 13 ± 3 nm, negatively charged, and green emissive. GB-CDs contained amino groups, which enabled their binding to Fe3+, resulting in their fluorescence quenching. Based on this, GB-CDs were employed to detect Fe3+ with high selectivity, showing a linear detection range of 10–70 μM and a detection limit of 3.6 nM. Furthermore, the addition of ATP can recover the fluorescence quenching of GB-CDs by Fe3+. Therefore, the GB-CD + Fe3+ system was deployed to assay ATP with a linear detection range of 50–600 μM and a detection limit of 60 nM, exhibiting high sensitivity and specificity. GB-CDs and GB-CDs + Fe3+ were individually harnessed to assess Fe3+ in tap water and ATP in fetal bovine serum. More importantly, GB-CDs can enter cells to localize in mitochondria for mitochondrial imaging with high biocompatibility and superior photostability. As a result, GB-CDs and GB-CD + Fe3+ system were implemented to track Fe3+ and ATP in mitochondria of A549, respectively. This study provides a potent tool to monitor Fe3+ and ATP in mitochondria, expanding the application of CDs as biosensors for biological compounds in subcellular organelles.

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Quick synthesis of fluorescent nitrogen-doped carbon nanoparticles for selective and sensitive Fe(III) detection in water

Cited by 11 publications

References 9 publications

A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

Hydrothermal Synthesis of Nitrogen-Doped and Excitation-Dependent Carbon Quantum Dots for Selective Detection of Fe3+ in Blood Plasma

Biomass-Based Carbon Dots for Fe³⁺ and Adenosine Triphosphate Detection in Mitochondria

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Quick synthesis of fluorescent nitrogen-doped carbon nanoparticles for selective and sensitive Fe(III) detection in water

Cited by 11 publications

References 9 publications

A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

A Facile Synthesis of Green‐Blue Carbon Dots from Artocarpus lakoocha Seeds and Their Application for the Detection of Iron (III) in Biological Fluids and Cellular Imaging

Hydrothermal Synthesis of Nitrogen-Doped and Excitation-Dependent Carbon Quantum Dots for Selective Detection of Fe3+ in Blood Plasma

Biomass-Based Carbon Dots for Fe3+ and Adenosine Triphosphate Detection in Mitochondria

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Product

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Biomass-Based Carbon Dots for Fe³⁺ and Adenosine Triphosphate Detection in Mitochondria