2017
DOI: 10.1016/j.spinee.2016.09.016
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Quiescent pluripotent stem cells reside within murine peripheral nerves that can be stimulated to proliferate by recombinant human bone morphogenic protein 2 or by nerve trauma

Abstract: Exposure to BMP-2 causes a marked proliferation of previously quiescent cells within peripheral nerves. These cells simultaneously express KLF4, Sox2, Oct4, and c-Myc, the transcription factors that confer embryonic pluripotency. Work described in the companion paper reveals some of the differentiation capacity of the cells and their likely clinical significance. In addition, the effects of direct exposure of nerves to rhBMP-2 as described here should clearly illuminate the mechanism of BMP-2-related nerve com… Show more

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Cited by 9 publications
(21 citation statements)
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“…They also did not require feeder cells to survive. However, in contrast to the rodent cells [10] which were remaining dispersed on the culture plate, the human cells tended to gather to form colonies. It appears that the motile cells formed clusters within 24 to 48 hours in the stem cell medium, and stayed in colonies during proliferation.…”
Section: Resultsmentioning
confidence: 99%
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“…They also did not require feeder cells to survive. However, in contrast to the rodent cells [10] which were remaining dispersed on the culture plate, the human cells tended to gather to form colonies. It appears that the motile cells formed clusters within 24 to 48 hours in the stem cell medium, and stayed in colonies during proliferation.…”
Section: Resultsmentioning
confidence: 99%
“…Proliferating NEDAPS cells were isolated the same as reported previously for mouse NEDAPS cells [10]. Briefly, the minced nerve pieces were pelleted by centrifugation at 500xg for 5 minutes and followed by digestion in 0.2% (0.27 U/ml) collagenase (Worthington Biochemical Corp) at 37°C for 90 minutes.…”
Section: Methodsmentioning
confidence: 99%
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