Quinazoline pharmacophore in therapeutic medicine

Abstract

This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic targets. It traverses numerous biological potentials of quinazoline in the contemporary time to allow researchers' unhindered access to the beneficial role of quinazoline in fighting infectious diseases for future drug discovery. This work provides broad overview of medicinal survey of quinazoline chemistry valuable in the discovery of more efficient clinical trials and to summarize the most promising molecular targets for drug design. Article Info

Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide

“…The 1,3-diazanaphthalene, or quinazoline, structural motif is a privileged pharmacological scaffold 1 found in a wide range of bioactive compounds designed for treating health conditions including cancer, inflammation, hypertension, obesity, and infection 2–6 . Similarly substituted anilines are key elements of bioactive compounds 7 and valuable industrial reagents 8,9 (Fig.…”

Alcohol amine-catalyzed CO2 conversion for the synthesis of quinazoline-2,4-(1H,3H)-dione in water

“…Quinazoline-2,4(1H,3H)-dione and its derivatives are important intermediates as key building blocks in the synthesis of remedial drugs for heart disease and hypertension. 6,7 They are usually prepared with toxic and environment-unfriendly reagents, such as phosgene, 8 potassium cyanate 9 and isocyanate. 10 Recently, it has been reported that quinazoline-2,4(1H,3H)-dione could be prepared via the coupling of CO 2 and 2-aminobenzonitriles.…”

Synthesis and antimicrobial activity of novel 1,2,3‐triazole‐conjugates of quinazolin‐4‐ones

“…Quinazolines and their carbonyl derivatives, namely quinazolinones, are important structural motifs present in many natural and synthetic compounds exhibiting diverse biological activities like soporific, sedative, antidiabetic, antibacterial, antifungal, anticancer, anticonvulsant, antimalarial, antiinflamatory, antiviral, etc . A list of already approved marketed drugs includes several compounds containing quinazoline pharmacophore, e.g., 6,7‐dimethoxyquinazolin‐4‐amine derivatives such as prazosin, terazosin, alfuzosin, and doxazosin .…”