Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

Abstract

Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.

Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E

“…During previous research to identify novel fibronectin expression regulatory factors from fungal secondary metabolites, we isolated novobenzomalvins A–C from the fungus Aspergillus novofumigatus CBS117520 . These compounds were identified as quinazolinobenzodiazepine derivatives and were shown to up-regulate fibronectin expression in normal human neonatal dermal fibroblast primary cells.…”

Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds

“…The mass ion peak at m/z 514.258 in consonance with the molecular formula C 30 H 34 N 4 O 4 was also annotated as Novofumigatamide (17), which was formerly identified from Aspergillus novofumigatus CBS11520 as the new Aspergillus sp. [53]. In the same vein, metabolic profiling of the crude extracts of Aspergillus sp.…”

Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles

“…Among the new structures that have been isolated we can cite the novobenzomalvins A-C 52-54 shown in (Fig. 18) (from Aspergillus novofumigatus) that act as fibronectin expression regulators [82]. The molecules increased the fibronectin expression in normal human neonatal dermal fibroblast cells.…”