“…Non steroidal anti-inflammatory drugs (NSAIDs) have been used for the treatment of ailments such as pain, fever and inflammation and also in chronic conditions such as arthritis, psoriasis and asthma [115][116][117][118][119][120] . NSAIDs principally act by two different mechanisms: a direct contact mechanism on the gastro intestinal (GI) mucosa through oral dose and a generalized systemic action appearing after intravenous dosing 121,122 .…”