2011
DOI: 10.2174/092986711797535326
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Quinazolinone Analogs as Potential Therapeutic Agents

Abstract: Quinazolinone scaffold has been considered as a magic moiety possessing myriad spectrum of medicinal activities. Diversity of biological response profile has attracted considerable interest of several researchers across the globe to explore this skeleton for its assorted therapeutic significance. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, antiinf… Show more

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Cited by 67 publications
(35 citation statements)
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References 105 publications
(136 reference statements)
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“…Discussion 2,3-Disubstituted quinazolin-4(3H)-ones are fused heterocycles that are of considerable interest in medicinal chemistry because of thediverse rangeoftheir biological properties [2][3][4].Theyare importantbuilding blocks in thesynthesis of many natural products whichdisplay avariety of biological andpharmaceutical activities [5].T he diversity of chemicals tructureso ft he 4(3H)-quinazoline family andt heir useful biologicala ctivities made thesecompounds attractive targets in synthetic organic chemistry andm any studies haveb eenr eportedo nt he synthesiso ft hese compounds [6][7][8].T he titlec ompound( cf. fig.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Discussion 2,3-Disubstituted quinazolin-4(3H)-ones are fused heterocycles that are of considerable interest in medicinal chemistry because of thediverse rangeoftheir biological properties [2][3][4].Theyare importantbuilding blocks in thesynthesis of many natural products whichdisplay avariety of biological andpharmaceutical activities [5].T he diversity of chemicals tructureso ft he 4(3H)-quinazoline family andt heir useful biologicala ctivities made thesecompounds attractive targets in synthetic organic chemistry andm any studies haveb eenr eportedo nt he synthesiso ft hese compounds [6][7][8].T he titlec ompound( cf. fig.…”
Section: Methodsmentioning
confidence: 99%
“…The mixture of reaction was refluxed for 6hours. Thereafter, the mixture is cooled and 20 mL of saturatedNaHCO 3 solution was added and extracted with chloroform (3´50 mL). Theorganic solutionwas dried with sodium sulfate and distilled at vacuum.T he precipitate formed wasd ried and crystallized in methanol, obtaining 2.46 g(yield 71%) of yellow crystals.…”
Section: Source Of Materialsmentioning
confidence: 99%
“…Non steroidal anti-inflammatory drugs (NSAIDs) have been used for the treatment of ailments such as pain, fever and inflammation and also in chronic conditions such as arthritis, psoriasis and asthma [115][116][117][118][119][120] . NSAIDs principally act by two different mechanisms: a direct contact mechanism on the gastro intestinal (GI) mucosa through oral dose and a generalized systemic action appearing after intravenous dosing 121,122 .…”
Section: Anti-inflammatory Activitymentioning
confidence: 99%
“…Looking at the importance of these heterocyclic nuclei, it is thought of interest to accommodate 2-aminobenzothiazoles and fluoroquinolones in single molecular framework and screen them for their various biological activities. Due to our continuous interest [23][24][25][26] and research program on design and synthesis of novel anti-microbial agents a number of potent fluoroquinolone derivatives [27][28][29] have been synthesized. Recently, we have reported synthesis of novel fluoroquinolone derivatives annulated with benzothiazoles with promising anti-bacterial activity 30 .…”
Section: Research Articlementioning
confidence: 99%