Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

Abstract

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

Synthesis of 2,3-dihydroquinazolinones using nano-ovalbumin as a non-toxic biocatalyst

“…2,3-Dihydroquinazolin-4(1H)-ones are a significant class of heterocyclic compounds that form vary useful moiety of pharmaceutical, agricultural chemical and veterinary products [1,2]. Quinazolinone and its derivatives have many biological and medicinal activities such as anticonvulsant [3], antitumor [4], anticancer [5], hypnotic/sedatives [6], antimalarial [7], antibacterial and antioxidant [8], antimicrobial [9], antifungal and cytotoxic [10], antiproliferative [11], and inhibitory activities on α-glucosidase [12]. Several examples of marketed drugs with the 2,3-dihydroquinozolinones (DHQ) framework are shown in Fig.…”

Synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones in the presence of Fe3O4@nano‐cellulose–OPO3H as a bio‐based magnetic nanocatalyst

“…Quinazolinones and their derivatives are used to synthesize similar drugs such as hypnotic/sedatives and antimalarial, antibacterial and antioxidant, antitumor, antifungal and cytotoxic, antiproliferative, and inhibitory activities on α‐glucosidase . In Figure , the structure of metolazon (hypertensive), febrifugine (antimalaria), and methaqualone (sedative) were shown.…”