Quinazolinone-dihydropyrano[3,2-b]pyran hybrids as new α-glucosidase inhibitors: Design, synthesis, enzymatic inhibition, docking study and prediction of pharmacokinetic

Synthesis and Some Properties of New 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones

“…One of the most accessible methods of functionalization of kojic acid is its transformation into bromo-or chlorokojic acid 11, with further replacement of the halogen atom by various nucleophiles such as thioureas [28][29][30][31][32][33], alkyl mercaptans [29,30,34], thiophenols [21,35], sodium arylsulfinates [36], alkali metal thiocyanates [36][37][38][39], S-glycosylisothiuronium salts [40], various mercaptoazoles [22,25,28,29,41], 2-mercaptopyrimidines [24,42], 2-mercaptoquinazolines [43,44], mono-and dithiophosphates [45,46]. Many of the compounds obtained in this way are of interest for agrochemistry as growth regulators and herbicides comparable in efficiency to Fluazifop-P [29], or as insecticides [45,46].…”

A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes

“…2). However, they suffer from various side effects specially gastrointestinal problems and following that, a wide range of studies have been conducted on the anti-a-glucosidase activity of natural [17][18][19] and synthetic heterocyclic compounds [20][21][22][23][24][25][26][27] since the efficacy of a-GIs in the treatment of T2DM has been completely proven. Biological activity of metal ions and their complexes 28,29 have made them an important topic in drug discovery research.…”

One-pot multi-component synthesis of novel chromeno[4,3-b]pyrrol-3-yl derivatives as alpha-glucosidase inhibitors

“…Nojirimycin, miglitol, and voglibose are other market anti-α-glucosidase drugs for T2DM [ 17 , 18 ]. Meanwhile, various synthetic small-molecules of α-glucosidase inhibitors have been developed bearing imidazole [ 19 ], pyrazoles [ 20 ], quinazolinone [ 21 ], isatin [ 22 ], xanthone [ 23 ], and azole [ 24 ] groups.…”