Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents

Synthesis and Crystal Structure of 3-(4-Methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

“…It is a very important heterocycle exhibiting excellent pharmacological activities such as antimicrobial [2], antifungal [3], antitumor [4], anticancer [5], antiinflammatory [6], antidepressant [7], and anticonvulsant [8] activities. 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one are derivatives of quinazolinones have a wide range of pharmacological and biological activities such as anticonvulsant and antitumor [9].…”

Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function

“…Benzo[d] [1,3]oxazin-4-one derivatives 2 were prepared according to the reported methods [34]. The synthesis of 2-methyl-3-alkylquinazolin--4-one 3 and 2-styryl-3-alkylquinazolin-4-one 4 was carried out as reported with slight modifications [35].…”

Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents

“…[61][62][63][64][65][66][67][68][69][70][71][72][73] A series of PBD conjugates by linking different DNA interacting ligands such as benzimidazoles, benzothiazoles, naphthalimides, aryl substituted naphalens, chalcones and poly-aromatic hydrocarbons (pyrene amine, chrysene amine and phenanthrinephenyl) by using varying linker length to enhance the DNA binding affinity and antitumour activity. PBDmorpholine, N-methyl piperizine and N,N-dimethyl amine hybrids have been prepared in an attempt to improve the water solubility and cytotoxicity of the PBD compounds.…”