Quinine- and Quinidine-dependent Antiplatelet Antibodies

Pfueller, Sharron L.; Hosseinzadeh, Pari; Firkin, Barry G.

doi:10.1172/jci110109

Cited by 17 publications

(3 citation statements)

References 12 publications

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“…93 Further studies by these investigators demonstrated that Factor VIII-related antigen was the plasma factor required for the in vitro transformation of sensitized lymphocytes. 144 Significantly less lymphocyte transformation occurred in the presence of serum from patients with von Willebrand's disease, and the addition of purified Factor VIII antigen to test sera restored transformation to normal levels. 144 These studies suggest that drug, antibody, Factor VIII-related antigen, and platelet glycoprotein 1 interact to form "complete antigen," which initiates lymphocyte transformation and possibly the biosynthesis of quinine or quinidine-dependent antiplatelet antibodies.…”

Section: The Drug and Plasma Component Might Altermentioning

confidence: 98%

“…144 Significantly less lymphocyte transformation occurred in the presence of serum from patients with von Willebrand's disease, and the addition of purified Factor VIII antigen to test sera restored transformation to normal levels. 144 These studies suggest that drug, antibody, Factor VIII-related antigen, and platelet glycoprotein 1 interact to form "complete antigen," which initiates lymphocyte transformation and possibly the biosynthesis of quinine or quinidine-dependent antiplatelet antibodies. It remains uncertain whether the plasma Factor VIII-related antigen is required for the binding of antibody to the platelet membrane.…”

Section: The Drug and Plasma Component Might Altermentioning

confidence: 98%

See 1 more Smart Citation

Drug-Induced Platelet Destruction

Hackett¹,

Kelton²,

Powers³

1982

Semin Thromb Hemost

100

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Section: The Drug and Plasma Component Might Altermentioning

confidence: 98%

Section: The Drug and Plasma Component Might Altermentioning

confidence: 98%

Drug-Induced Platelet Destruction

Hackett¹,

Kelton²,

Powers³

1982

Semin Thromb Hemost

100

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“…This raised the possibility that vWf:Ag may be involved in events mediating damage to platelets subsequent to drug-dependent IgG binding. Further confusion has arisen from our inability to confirm our earlier findings that vWf:Ag corrected the defective responses of vWd platelets to Q.Ab (11). Thus, in this study we have reinvestigated the susceptibility of platelets from different individuals, both normal or with vWd, to drug-dependent anti body-mediated activation and compared it to drug-dependent IgG binding.…”

Section: Introductionmentioning

confidence: 93%

Differing Susceptibilities of Platelets from Normal Individuals and Patients with von Willebrand’s Disease to Attack by Quinine- and Quinidine-Dependent Antiplatelet Antibodies

et al. 1989

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SummaryReactivity of quinine- and quinidine-dependent antiplatelet antibodies has been compared in platelet-rich-plasma (PRP) from normal donors and from patients with von Willebrand’s disease (vWd). One quinine-dependent antibody (Q. Ab) caused platelet aggregation and [14C] serotonin release with only 7 of 12 normal donors, while another Q. Ab and a quinidine-dependent antibody (Qd. Ab) caused aggregation and release with all 12. Drug- dependent IgG binding and PF 3 availability induced by the antibodies were, however, comparable in all donors. Differences in responsiveness were associated with platelets and not plasma. vWd platelets showed normal drug-dependent IgG binding, but decreased aggregation and serotonin release to most drug- dependent antibodies. Responsiveness was not restored by purified vWf:Ag, but, in one case, was corrected by normal plasma or cryoprecipitate. Drug-dependent binding of the Q. Ab which caused variable responsiveness in normals was to the same platelet antigens (GPIb and GPIIIa) in both normal and vWd platelets and did not require plasma components. Reduced PF 3 availability was seen with some antibodies in some vWd patients. Plasma from two of these patients inhibited aggregation of normal platelets to Q. Ab and one of these inhibited aggregation to ADP. Antiplatelet antibodies were detected in these two plasmas by ELISA. Thus some Q. Ab produce different responses with platelets from different donors. In vWd, reduced responsiveness to Q.Ab and Qd. Ab may result from production of inhibitory antiplatelet antibodies.

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Immunology of the Platelet Surface

Pfueller

1985

Platelet Membrane Glycoproteins

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Quinine- and Quinidine-dependent Antiplatelet Antibodies

Cited by 17 publications

References 12 publications

Drug-Induced Platelet Destruction

Drug-Induced Platelet Destruction

Differing Susceptibilities of Platelets from Normal Individuals and Patients with von Willebrand’s Disease to Attack by Quinine- and Quinidine-Dependent Antiplatelet Antibodies

Immunology of the Platelet Surface

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