Quinine Sensitivity

Calnan, C. D.; Caron, G. A.

doi:10.1136/bmj.2.5269.1750

Cited by 21 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contact dermatitis due to the topical application of preparations containing quinine has been described by several authors (Burgess & Usher 1930, Ford 1934, Urbach & Gottlieb 1946, Calnan & Caron 1961, and in view of this we decided to investigate further this apparent outbreak of reactions to quinine among workers at this factory. was impressed by the number of his patients who were complaining of reactions to quinine.…”

mentioning

confidence: 89%

Quinine dermatitis: Investigation of a factory outbreak

et al. 1978

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 89%

Quinine dermatitis: Investigation of a factory outbreak

et al. 1978

View full text Add to dashboard Cite

show abstract

“…In seven patients who were reported because of dermatologic reactions, quinine-containing topical lotions were responsible. In one man, perineal and genital eczema were attributed to his wife's quinine-containing contraceptive pessary [21]. A factory that purified quinine had an outbreak of dermatitis attributed to quinine in 13 workers [22]; two workers who were described in detail were included in our review.…”

Section: Systematic Review: Adverse Reactions To Quininementioning

confidence: 99%

Diversity and severity of adverse reactions to quinine: A systematic review

et al. 2016

View full text Add to dashboard Cite

Quinine is a common cause of drug-induced thrombocytopenia and the most common cause of druginduced thrombotic microangiopathy. Other quinine-induced systemic disorders have been described. To understand the complete clinical spectrum of adverse reactions to quinine we searched 11 databases for articles that provided sufficient data to allow evaluation of levels of evidence supporting a causal association with quinine. Three reviewers independently determined the levels of evidence, including both immune-mediated and toxic adverse reactions. The principal focus of this review was on acute, immunemediated reactions. The source of quinine exposure, the involved organ systems, the severity of the adverse reactions, and patient outcomes were documented. One hundred-fourteen articles described 142 patients with definite or probable evidence for a causal association of quinine with acute, immune-mediated reactions. These reactions included chills, fever, hypotension, painful acral cyanosis, disseminated intravascular coagulation, hemolytic anemia, thrombocytopenia, neutropenia, acute kidney injury, rhabdomyolysis, liver toxicity, cardiac ischemia, respiratory failure, hypoglycemia, blindness, and toxic epidermal necrolysis. One hundred-two (72%) reactions were caused by quinine pills; 28 (20%) by quinine-containing beverages; 12 (8%) by five other types of exposures. Excluding 41 patients who had only dermatologic reactions, 92 (91%) of 101 patients had required hospitalization for severe illness; 30 required renal replacement therapy; three died. Quinine, even with only minute exposure from common beverages, can cause severe adverse reactions involving multiple organ systems. In patients with acute, multi-system disorders of unknown origin, an adverse reaction to quinine should be considered.

show abstract

“…Par ailleurs, l’écorce brute de quinquina, destinée à des infusions ou des tisanes, se trouve librement en herboristerie. Par ailleurs, la littérature ayant rapporté un cas de dermatite aiguë du scalp, de la face, du cou et de la main gauche, survenue un jour après l’usage d’eau de quinine [52] , ayant engendré une hospitalisation d’une semaine, documentée par un patch test positif à 2 % de sulfate de quinine, nous avons cru bon mentionner un shampoing contenant un extrait de quinine ( Tableau 4 ).…”

Section: Discussionunclassified

Eau tonique et quinine – un cocktail de bicentenaire servi en pleine effervescence

Lefrère

Barbaud

Bagot

et al. 2021

Revue Française d'Allergologie

View full text Add to dashboard Cite

Objectifs de l’étude La pandémie à SARS-CoV-2 voit nombre de médias relayer la présence de quinine dans les eaux toniques. Si son effet antiviral a été soulevé in vitro , l’amalgame avec ses dérivés, comme l’hydroxychloroquine, suscite un attrait pour ces eaux. Dans le cadre supplémentaire du bicentenaire de la découverte de la quinine, l’objectif principal vise à analyser les réactions d’hypersensibilité liées à la consommation de boissons contenant de la quinine décrites dans la littérature. Patients et méthodes Nous avons analysé les cas publiés indexés sur Pubmed , Scopus , Google Scholar. Un score d’imputabilité de la quinine a été calculé pour chacune des observations. Un dosage de quinine a été pratiqué sur plusieurs breuvages dont la vérification de teneur n’avait pas fait l’objet de publication. Résultats En parallèle d’études pharmacocinétiques connexes, ce corpus compte 26 observations. Elles concernent principalement des hommes jeunes, dont la gravité des symptômes est variable : essentiellement dermatologique, avec érythème pigmenté fixe, exanthème généralisé, urticaires ; hématologique, avec thrombopénie, syndrome hémorragique, microangiopathie thrombotique ; plus rarement oculaire, cardiaque ou auditive. Le niveau d’imputabilité de la quinine est certain pour trois cas, probable pour vingt-deux, possible pour deux. Les teneurs testées des apéritifs et d’un vin cuit, toutes conformes aux normes, sont moindres que celle des eaux toniques. Discussion Peut-être sous diagnostiqué, le mécanisme majoritaire est de type immuno-allergique, sans qu’une réaction croisée avec d’autres quinoléines ait pu être montrée. Chez ces patients et les femmes allaitantes de nouveau-nés déficitaires en G6PD, tout médicament, phytothérapie, homéopathie, voire cosmétique contenant de la quinine, sur la base d’une liste didactique proposée, seraient à écarter.

show abstract

Quinine Sensitivity

Cited by 21 publications

References 3 publications

Quinine dermatitis: Investigation of a factory outbreak

Quinine dermatitis: Investigation of a factory outbreak

Diversity and severity of adverse reactions to quinine: A systematic review

Eau tonique et quinine – un cocktail de bicentenaire servi en pleine effervescence

Contact Info

Product

Resources

About