Quinoid glycosides from Forsythia suspensa

“…It also presented the minor fragments at m/z 161 and m/z 135, corresponding to caffeic acid. Considering the data reported by Sun et al, [12] and Li et al, [14] and also the common presence of phenylethanoid glycosides in Veronica genus, [15] peak 11 was tentatively identified as forsythenside K.…”

Section: Hydroxycinnamoyl Derivativesmentioning

confidence: 73%

Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg.

Živković

Barreira

Šavikin

et al. 2017

Chemistry & Biodiversity

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Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6‴-O-acetyl)-b-allosyl (1‴?2‴)-b-glucoside were the major phenolics in V. teucrium. Additionally, the antineurodegenerative activity was tested at concentrations of 25, 50, and 100 lg/ml using acetylcholinesterase (AChE) and tyrosinase (TYR) assays. The inhibition of both enzymes was achieved with the investigated extracts, ranging from 22.78 to 35.40% for AChE and from 9.57 to 16.38% for TYR. There was no statistical difference between the activities of the analyzed extracts. Our data indicate that V. teucrium and V. jacquinii may have beneficial effects against Alzheimer's and Parkinson's disease.

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“…and F. suspensa , and their structures were elucidated and unequivocally identified by spectroscopic methods. All reference standards were unambiguously identified by 1 H, 13 C–NMR technique in our laboratory (Li et al, ). SHL was purchased from SanJing Pharm Co. Ltd (no.…”

Section: Methodsmentioning

confidence: 99%

A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang‐Huang‐Lian oral liquid by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry

Zhang

Yao

et al. 2017

Biomedical Chromatography

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A target and nontarget strategy based on in-house chemical components library was developed for rapid and comprehensive analysis of complicated components from traditional Chinese medicine preparation Shuang-Huang-Lian oral liquid. The sample was analyzed by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry using generic acquisition parameters. Automated detection and data filtering were performed on the UNIFI™ software and the detected peaks were evaluated against an in-house library. As a result, a total of 170 chemical components (110 target compounds and 60 nontarget ones) were identified or tentatively characterized, including 54 flavonoids, 30 phenylethanoid glycosides, 16 iridoid glycosides, 14 lignans, 32 organic acids, 19 triterpenoid saponins and five other types of compounds. Among them, 44 compounds were further confirmed by comparison with reference standards. It was demonstrated that this systematical approach could be successfully applied for rapid identification of multiple compounds in traditional Chinese medicine and its preparations. Furthermore, this work established the foundation for the further investigation on the metabolic fates of multiple ingredients in Shuang-Huang-Lian oral liquid.

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Quinoid glycosides from Forsythia suspensa

Cited by 45 publications

References 33 publications

Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS

Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS

Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg.

A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang‐Huang‐Lian oral liquid by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry

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