Quinoid radio-toxin (QRT) induced metabolic changes in mice: An ex vivo and in vivo EPR investigation

Ibragimova, M. I.; Petukhov, V. Yu.; Zheglov, E. P.; Khan, Nadeem; Hou, Huagang; Swartz, Harold M.; Konjukhov, G. V.; Низамов, Р. Н.

doi:10.1016/j.niox.2008.01.002

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Morphological and functional changes, observed in irradiated products, are happening due to the adsorption of energy released during gamma radiation 7 . Several hypotheses attempted to explain the mechanism of gamma rays-induced cell injury 8 - 12 : increased permeability of cellular membrane 8 , dysfunction of enzymes 9 and generation of radiotoxins 10 . Regardless of the fact that these hypotheses are well documented, it is now widely accepted, based on the significant number of experimental proofs, that damage of deoxyribonucleic acid (DNA) is mainly responsible for detrimental effects of gamma radiation 11 - 12 .…”

Section: Molecular Mechanisms Involved In Gamma Rays-induced Cell Dammentioning

confidence: 99%

Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin

Harrell¹,

Djonov

Fellabaum³

et al. 2018

Int. J. Med. Sci.

133

102

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The standard sterilization method for most medical devices over the past 40 years involves gamma irradiation. During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors. Accordingly, gamma radiation significantly alters biomechanical properties of bone, tendon, tracheal, skin, amnion tissue grafts and micronized amniotic membrane injectable products. Similarly, when polymer medical devices are sterilized by gamma radiation, their physico-chemical characteristics undergo modification significantly affecting their clinical use.Several animal studies demonstrated that consummation of irradiated food provoked genome instability raising serious concerns regarding oncogenic potential of irradiated consumables. These findings strongly suggest that new, long-term, prospective clinical studies should be conducted in near future to investigate whether irradiated food is safe for human consumption. In this review, we summarized current knowledge regarding molecular mechanisms responsible for deleterious effects of gamma radiation with focusing on its significance for food safety and biomechanical characteristics of medical devices, and tissue allografts, especially injectable biologics.

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Section: Molecular Mechanisms Involved In Gamma Rays-induced Cell Dammentioning

confidence: 99%

Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin

Harrell¹,

Djonov

Fellabaum³

et al. 2018

Int. J. Med. Sci.

133

102

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“…Paramagnetic substances contain unpaired electrons, allowing free radicals and ROS in the skin to be detected [29]. Spin marker and spin traps in combination with L-and S-band EPR are often used for the analysis of radical production, pH measurements or oximetry in vivo/ex vivo [22,[30][31][32][33][34][35]. The studies reviewed herein focused on the determination of the antioxidant potential in vivo.…”

Section: Technical Aspects Of the Performance Of In Vivo Epr-measuremmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

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“…Functional changes observed in irradiated shrimps could due to the adsorption of energy released during gamma radiation (Farkas, 1998). Several hypotheses attempted to explain the mechanism of gamma rays-induced cell injury (Al-Zahrani & Al-Sewaidan, 2017;Kuefner et al, 2015;Sage & Shikazono, 2017): increased permeability of the cellular membrane, dysfunction of enzymes and generation of radiotoxins (Al-Zahrani & Al-Sewaidan, 2017;Ibragimova et al, 2008;Rendic & Guengerich, 2012). Notwithstanding, these hypotheses are well documented and now widely accepted, based on the significant number of experimental pieces of evidence, that damage of deoxyribonucleic acid (DNA) is mainly responsible for the detrimental effects of gamma radiation.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of gamma irradiation and proper packaging for the control of insects in smoked shrimps (Penaeus notialis) from three different water bodies in Ghana

Akuamoa

Odamtten

Kortei

2020

Cogent Food & Agriculture

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Damage caused to stored dried shrimps by insect pests is problematic and are often underestimated. The incubation, identification, and control of these insect pests which infest shrimps from three water sources; sea, lagoon, and river were evaluated according to standard procedures of the Entomological Society of Canada. Exposure to gamma ionizing radiation was undertaken from a Cobalt 60 source (SL 515, Hungary) and radiation doses of 0, 4, 8, and 10 kGy at a rate of 1.7 kGy/hr were used. The hidden insects identified were Necrobia rufipes (Copra beetle), Dermestes maculatus De Geer (Hide beetle), and a mite Lardoglyphus sp. belonging to the family Acaridae in the mite group Astigmata. An after-feeding test on shrimps by insects revealed a weight reduction by 17%, 14%, and 26% for sea, lagoon, and riverine shrimps respectively. These observations were statistically significant at p ≤ 0.05 level. After 2 months of storage there was generally a 43.0 % reduction in weight which was significantly different (p ≤ 0.05) from the initial ABOUT THE AUTHORS Mrs Felicia Akuamoa is an M.phil.(Radiation Processing) holder from University of Ghana. She is a Doctoral student at the Wageningen Agricultural University, Holland. She works as a Research Scientist at the Ghana Atomic Energy Commission. Her research areas include in-vitro antioxidant analysis and radiation processing of foods.Prof. George Tawia Odamtten holds a Ph.D in Agriculture & Food Safety from the Wageningen Agricultural University, Holland. He is a Full Professor of Mycology and Plant Pathology at University of Ghana. His research areas include fungal pathogens of crops, food borne fungal contaminants, fungal biotechnology and mycotoxin analysis.Dr. Nii Korley Kortei holds a Ph.D in Radiation Processing (Food Science option

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Quinoid radio-toxin (QRT) induced metabolic changes in mice: An ex vivo and in vivo EPR investigation

Cited by 5 publications

References 19 publications

Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin

Risks of Using Sterilization by Gamma Radiation: The Other Side of the Coin

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Synergistic effect of gamma irradiation and proper packaging for the control of insects in smoked shrimps (Penaeus notialis) from three different water bodies in Ghana

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