Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant

Carvalho, Patricia Ribeiro de; Ropero, Denise Ricoy; Pinheiro, Mariana Martins Gomes; Fernandes, Patrícia Dias; Boylan, Fábio

doi:10.1371/journal.pone.0164998

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…arizonica, were investigated for antinociceptive activity. 210 At the doses of 3 and 10 mg/kg, these two N. Antinociceptive Activity furoquinoline alkaloids were twofold more potent than morphine in treated animals using the hot plate model. Furthermore, mechanistic studies indicated that the opiate and nitric oxide (NO) system may play an important role in the antinociceptive activity.…”

Section: Antinociceptive Activitymentioning

confidence: 94%

“…Anhydroevoxine and choisyine ( 246 ) (Figure ) from Choisya Aztec‐Pearl, a hybrid of Choisya ternata and Choisya dumosa var. arizonica , were investigated for antinociceptive activity . At the doses of 3 and 10 mg/kg, these two furoquinoline alkaloids were twofold more potent than morphine in treated animals using the hot plate model.…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

“…Furthermore, mechanistic studies indicated that the opiate and nitric oxide (NO) system may play an important role in the antinociceptive activity. The cholinergic system may also be involved …”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

160

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Antinociceptive Activitymentioning

confidence: 94%

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

160

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“…Alkaloids are generally toxic to man and many of them have shown physiological activities; hence they are widely used in medicine 13 . Quinolene alkaloid also reported in leaf extract of T. falciformis, previous studies on Quinolene reveals that it has antinociceptive 16 and antifungal activity 17 . Likewise, terpenoids are isoprene molecules that are significant not only in plant growth and ecology but also provide a shield against insects.…”

Section: Resultsmentioning

confidence: 81%

Untitled

2020

IJPSR

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Present study was conducted to identify and characterize the phytoconstituents of methanolic extract of leaves of Tephrosia falciformis (Pers.) Ramaswami of family Fabaceae. The methanolic extract of leaves was subjected to qualitative screening for primary and secondary metabolites as per standard methods; further GC-MS analysis was carried out for the identification of secondary metabolites. The preliminary analysis of leaf extract confirmed the presence of primary as well as secondary phytoconstituents such as phenolic compounds, alkaloids, flavonoids, terpenoids, phytosterols, etc. in methanolic extract. GC-MS analysis of extract revealed the presence of 53 phytochemicals. The presence of various compounds with different chemical groups like quinolene, piperdinone (alkaloids), Neophytadiene (sesqueterpenens), phytol (diterpene alcohol), sitosterol, stigmasterol (sterols) and many fatty acids including their derivatives in considerable amount gives the good prospect for the use of this plant in pharmaceutical preparations to cure health-related problems.

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“…Hot plate test is a simple and extensively used method to investigate the central antinociceptive activity of drugs. 41 Both hot plate and tail flick models have been implicated, assessing the antinociceptive action of drugs in modulating acute thermal pain. However, the neurological mechanism of pain modulation is different in these models.…”

mentioning

confidence: 99%

ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

Venkatakrishna¹,

K²,

HV³

et al. 2022

JPR

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Plant-based natural products as anti-nociceptors have enormous potential as safer alternatives to conventional opiates and NSAIDS. Piper nigrum (black pepper) is one of the major culinary spices with medicinal attributes. Methods: In the present study, the antinociceptive activity of a standardized black pepper seed extract (Viphyllin) containing not less than 30% β-caryophyllene (BCP) was evaluated using pain models in mice, namely acetic acid-induced writhing test, formalin-induced paw licking test, hot plate test and tail flick test. Further, the antagonists SR141716A (0.1 mg/kg i.p.), AM630 (5 mg/kg i.p.), capsazepine (0.1 mg/kg body weight i.p.), and GW6471 (1 mg/kg i.p.) were used to evaluate the involvement of cannabinoid receptors CB1 and CB2, TRPV1 ion channel and PPARα receptor, respectively. Molecular docking (AutoDock 4.2) was used to study the interaction of BCP with the agonist-binding sites of the selected pain receptors. Results: Viphyllin at 10 mg, 25 mg and 50 mg/kg (i.p.) significantly inhibited the writhings in mice as compared to untreated control group (p < 0.001). Further, Viphyllin at 50 mg/kg showed strong antinociceptive effect in formalin-induced paw licking test (p < 0.05). Pretreatment of mice with AM630 significantly reversed the antinociceptive activity of Viphyllin in both early and late phases of formalin test (p < 0.05). Administration of Viphyllin markedly increased the latency time of mice in hot plate test (p < 0.001). Further, Viphyllin markedly increased the latency time of tail flick compared to control group from 30 min to 90 min after treatment. AM630, Capsazepine, and GW6471 abolished the analgesic effect of Viphyllin. These findings clearly suggest the involvement of CB2 receptor, TRPV1 ion channel and PPARα receptor activation in Viphyllin-mediated antinociceptive activity. Docking score predictions further supported the possible involvement of BCP in the antinociceptive mechanism of Viphyllin. Conclusion:In conclusion, Viphyllin could be a natural pain-relieving agent involving safer pain signaling mechanisms, unlike conventional opiates and NSAIDs.

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Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant

Cited by 7 publications

References 41 publications

Biologically active quinoline and quinazoline alkaloids part II

Biologically active quinoline and quinazoline alkaloids part II

Untitled

ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels

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