Quinoline-pyrimidine hybrid compounds from 3-acetyl-4-hydroxy-1-methylquinolin-2(1H)-one: Study on synthesis, cytotoxicity, ADMET and molecular docking
“…Karpoormath et al synthesized quinoline–pyrimidine hybrids and screened them for antiplasmodial activity. 56 displayed promising activity with IC50 of 0.32 μM (Kayamba et al, 2021; Toan et al, 2020). …”
Section: Antimalarial Activitymentioning
confidence: 99%
“…Hybrid 54 exhibited excellent liver stage activity with IC50 of 1.5 µM (Kaur et al, 2015;Rogerio et al, 2020). 56 displayed promising activity with IC50 of 0.32 μM (Kayamba et al, 2021;Toan et al, 2020).…”
Nitrogen containing heterocycles have a quintessential role in synthetic chemistry, cell biology and are part of enormous natural products. Compounds of these classes playing a cardinal role are the six-membered unsaturated rings having nitrogen referred as azines. Similar analogues with two ring nitrogen are termed as diazines. The diazines exist in three isomeric forms depending on the position of the nitrogen, pyridazine (1, 2-diazine), pyrimidine (1, 3-diazine), and pyrazine (1, 4-diazine) (Figure 1). Pyrimidines have remarkable biotic relevance and are the omnipresent isomer among the diazines (
“…Karpoormath et al synthesized quinoline–pyrimidine hybrids and screened them for antiplasmodial activity. 56 displayed promising activity with IC50 of 0.32 μM (Kayamba et al, 2021; Toan et al, 2020). …”
Section: Antimalarial Activitymentioning
confidence: 99%
“…Hybrid 54 exhibited excellent liver stage activity with IC50 of 1.5 µM (Kaur et al, 2015;Rogerio et al, 2020). 56 displayed promising activity with IC50 of 0.32 μM (Kayamba et al, 2021;Toan et al, 2020).…”
Nitrogen containing heterocycles have a quintessential role in synthetic chemistry, cell biology and are part of enormous natural products. Compounds of these classes playing a cardinal role are the six-membered unsaturated rings having nitrogen referred as azines. Similar analogues with two ring nitrogen are termed as diazines. The diazines exist in three isomeric forms depending on the position of the nitrogen, pyridazine (1, 2-diazine), pyrimidine (1, 3-diazine), and pyrazine (1, 4-diazine) (Figure 1). Pyrimidines have remarkable biotic relevance and are the omnipresent isomer among the diazines (
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