Quinoline, quinazoline and acridone alkaloids

Abstract

This review covers the isolation, structure determination, synthesis and biological activity of quinoline, quinazoline and acridone alkaloids from plant, microbial and animal sources: 134 references are cited.

Synthesis, anticonvulsant, antioxidant and binding interaction of novel N-substituted methylquinazoline-2,4(1H,3H)-dione derivatives to bovine serum albumin: A structure–activity relationship study

“…The quinazolinedione moiety is an important scaffold embedded in a variety of natural alkaloids [12,13]. In recent decades, quinazoline-2,4(1H, 3H)-diones have drawn the attention of chemists and medicinal chemists because of their various biological activities for use as anticonvulsants [14], antibacterial [15], psychosedative [16] and antihypertensive or hypotensive compounds [17].…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55]. For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) [60].…”

“…Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55]. For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55].…”

Recent Advances in Biomimetic Synthesis Involving Cyclodextrins

“…They exhibit remarkable biological activities like anti-malarial, anti-inflammatory, anti-asthmatic, anti-bacterial, antihypertensive, anti-tubercular, anti-alzheimer, anti-HIV, and anti-cancer (Michael, 2007;Suresh et al, 2009). In addition, quinolines are valuable synthons, used for the preparation of nano and mesostructures with enhanced electronic and photonic properties (Zhang et al, 1999;Jenekhe et al, 2001).…”