Quinolines: a new hope against inflammation

Mukherjee, Somenath; Pal, Manojit

doi:10.1016/j.drudis.2012.11.003

Cited by 93 publications

(42 citation statements)

References 68 publications

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“…The main use of quinoline is the manufacture of other specialty chemicals, as moiety to pharmaceuticals (Mukherjee and Pal 2013;Vezmar and Georges 2000) and to dyes (Lam et al 2012), and its presence in textile (Luongo et al 2014) and in dye processing plants effluents has been reported in the literature (Oliveira et al 2007;Yuan et al 2006). Even though no human studies on their carcinogenicity are available, tests involving acute exposure of mice have demonstrated quinoline and some of its methylated isomers to induce liver cancer (Hirao et al 1976;La Voie et al 1988).…”

Section: Responsible Editor: Ester Heathmentioning

confidence: 94%

The washout effect during laundry on benzothiazole, benzotriazole, quinoline, and their derivatives in clothing textiles

Luongo

Avagyan

Hongyu

et al. 2015

Environ Sci Pollut Res

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In two previous papers, the authors have shown that benzothiazole, benzotriazole, quinoline, and several of their derivatives are widespread in clothing textile articles. A number of these compounds exhibit allergenic and irritating properties and, due to their octanol-water partition coefficient, are prone to be absorbed by the skin. Moreover, they are slightly soluble in water, which could make washing of clothes a route of emission into the environment. In the present study, the washout effect of benzothiazole, benzotriazole, quinoline, and some of their derivatives has been investigated. Twenty-seven textile samples were analyzed before, as well as after five and ten times of washing. The most abundant analyte was found to be benzothiazole, which was detected in 85 % of the samples with an average concentration of 0.53 μg/g (median 0.44 μg/g), followed by quinoline, detected in 81 % of the samples with an average concentration of 2.42 μg/g (median 0.21 μg/g). The average decrease in concentration for benzothiazoles was 50 % after ten times washing, while it was around 20 % for quinolines. The average emission to household wastewater of benzothiazoles and quinolines during one washing (5 kg of clothes made from polyester materials) was calculated to 0.5 and 0.24 g, respectively. These results strongly indicate that laundering of clothing textiles can be an important source of release of these compounds to household wastewater and in the end to aquatic environments. It also demonstrates a potential source of human exposure to these chemicals since considerable amounts of the compounds remain in the clothes even after ten times of washing.

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Section: Responsible Editor: Ester Heathmentioning

confidence: 94%

The washout effect during laundry on benzothiazole, benzotriazole, quinoline, and their derivatives in clothing textiles

Luongo

Avagyan

Hongyu

et al. 2015

Environ Sci Pollut Res

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“…Quinoline derivatives are synthetic targets because they exhibit a wide range of biological and pharmacological activities [18][19][20][21][22][23]. Compared with other derivatives that exhibit high fluorescence, quinolone derivatives are among the best candidates in the design of electroluminescent materials [24,25].…”

Section: Introductionmentioning

confidence: 99%

Computational and Experimental Study on Molecular Structure of Benzo[g]pyrimido[4,5-b]quinoline Derivatives: Preference of Linear over the Angular Isomer

et al. 2017

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A series of 5-aryl-2-methylthio-5,12-dihydrobenzo[g]pyrimido [4,5-b]quinoline-4,6,11(3H) -trione was synthesized through an environmental friendly multicomponent methodology and characterized with FT-IR (Fourier Transform infrared spectroscopy), 1 H NMR (Nuclear Magnetic Resonance ), 13 C NMR and GC-MS (gas chromatography-mass spectrometry). The 5-(4-methoxyphenyl)-2-methylthio-5,12-dihydrobenzo[g]pyrimido [4,5-b]quinoline-4,6,11(3H)-trione 4c compound was characterized by X-ray single crystal diffraction. The geometry of 4c has been fully optimized using DFT (Density functional theory), B3LYP functional and 6-31G(d,p) basis set, thus establishing the ground state energy and thermodynamic features for the mentioned compound, which are in accordance with the experimental data and the crystal structure. The experimental results reveal a strong preference for the regioselective formation of 4c linear four fused rings over the angular four fused and suggest a possible kinetic control in product formation.

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“…The ulcer index was calculated according to the method of Pauls et al [34]. All drug doses were calculated according to Paget and Barnes [35]. As illustrated in table in table 4, the most active compounds 9c, 9e, 10a and 11a were devoid of any ulcerogenic activity.…”

Section: Ulcerogenic Activitymentioning

confidence: 99%

Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II

El‐Feky

El‐Samii

Osman

et al. 2015

Bioorganic Chemistry

120

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Quinolines: a new hope against inflammation

Cited by 93 publications

References 68 publications

The washout effect during laundry on benzothiazole, benzotriazole, quinoline, and their derivatives in clothing textiles

The washout effect during laundry on benzothiazole, benzotriazole, quinoline, and their derivatives in clothing textiles

Computational and Experimental Study on Molecular Structure of Benzo[g]pyrimido[4,5-b]quinoline Derivatives: Preference of Linear over the Angular Isomer

Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II

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