1998
DOI: 10.1016/s0960-894x(98)00201-7
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Quinolines as potent 5-lipoxygenase inhibitors: Synthesis and biological profile of L-746,530

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Cited by 269 publications
(79 citation statements)
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“…The starting material 2-amino-4,5-dimethoxybenzaldehyde 1 was obtained by reduction of 4,5-dimethoxy-2-itrobenzaldehyde according to our previous procedure [6]. Our approach to the synthesis of 2 were based on the Friedländer condensation strategy.…”
Section: Resultsmentioning
confidence: 99%
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“…The starting material 2-amino-4,5-dimethoxybenzaldehyde 1 was obtained by reduction of 4,5-dimethoxy-2-itrobenzaldehyde according to our previous procedure [6]. Our approach to the synthesis of 2 were based on the Friedländer condensation strategy.…”
Section: Resultsmentioning
confidence: 99%
“…We described a very efficient and environmentally friendly method for the synthesis of novel 9,10-dimethoxybenzo [6,7]oxepino [3,4-b]quinolin-13(6H)-ones 7a-p through the intramolecular Friedel-Crafts acylation, the hydrolysis, the Willamson reaction, the Wohl-Zeigler bromination and Friedländer condensation. The experimental procedure was very simple.…”
Section: Resultsmentioning
confidence: 99%
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“…From the available literature it's clear that the quinoline ring system and their fused derivatives are significant structural units and present as substructure in various alkaloids, therapeutics and synthetic analogues, which exhibit good biological activities (Larsen et al, 1996;Roma et al, 2000). Various quinolines derivatives are reported as anti-malarial, anti -inflammatory, antiasthmatic, antibacterial, anti-hypertensive and platelet derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibiting agents (Dube et al, 1998). A large variety of quinolines are reported to exhibit substantial anti-cancer activities (Alkasomi et al, 2010) Quinoline derivative act as anti-cancer agents through a variety of mechanisms for example; cell cycle arrest in the G2 phase (Kim et al, 2005) inhibition of topoisomerase (Ching et al, 2008) and tubulin polymerization inhibition (Alkasomi., 2009) Another mechanism of action is the inhibition of tyrosine kinases (Mulvihill et al, 2008).…”
Section: Introductionmentioning
confidence: 99%