Quinolones for uncomplicated acute cystitis in women

Rafalskiy, Vladimir V.; Andreeva, Irina V.; Rjabkova, Elena L

doi:10.1002/14651858.cd003597

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…In addition, three meta-analyses on general aspects of antibiotic therapy for acute uncomplicated cystitis [4][5][6] and one recently published meta-analysis on antibiotic versus placebo treatment of women with uncomplicated cystitis [7] were also considered. The studies were rated according to the level of evidence (LoE) and the grade of recommendation (GoR) using ICUD standards (for details see Preface) [8,9].…”

Section: Methodsmentioning

confidence: 99%

“…The same applies to other fluoroquinolones. According to a Cochrane analysis [4] all fluoroquinolones suitable for the treatment of UTI showed the same effectiveness for this indication, but the tolerability differed. Levofloxacin, for example, is used as 250 mg qd for 3 days and is as effective as ofloxacin 200 mg bid for 3 days, but has better tolerance [32].…”

Section: Fluoroquinolonesmentioning

confidence: 99%

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Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Naber

Wullt

Wagenlehner

2011

International Journal of Antimicrobial Agents

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Section: Methodsmentioning

confidence: 99%

Section: Fluoroquinolonesmentioning

confidence: 99%

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Naber

Wullt

Wagenlehner

2011

International Journal of Antimicrobial Agents

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“…Norfloxacin is a synthetic chemotherapeutic agent usually used to treat urinary tract infections [ 10 , 11 ]. Norfloxacin belongs to the third generation of quinolones.…”

Section: Introductionmentioning

confidence: 99%

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Bartoskova

Dobšíková

Stancová

et al. 2014

BioMed Research International

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The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In the Subchronic Toxicity Test, a significant (P < 0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found. In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase. From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.

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“…To date we have focused our attention primarily on enoxacin, which is a second generation fluoroquinolone antibiotic [ 99 ]. It was used in the United States for about ten years for the treatment of urinary tract infections and gonorrhea, and was voluntarily taken from the market in the US because of adverse effects including insomnia [ 100 ]. It is still used in much of the rest of the world as an antibiotic.…”

Section: Introductionmentioning

confidence: 99%

Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor

Toro¹,

Ostrov²,

Wronski³

et al. 2012

CPPS

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Binding between vacuolar H+-ATPases (V-ATPases) and microfilaments is mediated by an actin binding domain in the B-subunit. Both isoforms of mammalian B-subunit bind microfilaments with high affinity. A similar actin-binding activity has been demonstrated in the B-subunit of yeast. A conserved “profilin-like” domain in the B-subunit mediates this actin-binding activity, named due to its sequence and structural similarity to an actin-binding surface of the canonical actin binding protein profilin. Subtle mutations in the “profilin-like” domain eliminate actin binding activity without disrupting the ability of the altered protein to associate with the other subunits of V-ATPase to form a functional proton pump. Analysis of these mutated B-subunits suggests that the actin-binding activity is not required for the “housekeeping” functions of V-ATPases, but is important for certain specialized roles. In osteoclasts, the actin-binding activity is required for transport of V-ATPases to the plasma membrane, a prerequisite for bone resorption. A virtual screen led to the identification of enoxacin as a small molecule that bound to the actin-binding surface of the B2-subunit and competitively inhibited B2-subunit and actin interaction. Enoxacin disrupted osteoclastic bone resorption in vitro, but did not affect osteoblast formation or mineralization. Recently, enoxacin was identified as an inhibitor of the virulence of Candida albicans and more importantly of cancer growth and metastasis. Efforts are underway to determine the mechanisms by which enoxacin and other small molecule inhibitors of B2 and microfilament binding interaction selectively block bone resorption, the virulence of Candida, cancer growth, and metastasis.

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Quinolones for uncomplicated acute cystitis in women

Cited by 8 publications

References 15 publications

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor

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