Quintuplet Pregnancy: A Rare Case after Clomiphene Citrate Therapy and Review of Literature

Abstract

Multiple pregnancies are increasing with the progress in Assisted Reproductive Technology. The authors report a case of quintuplet pregnancy after Clomiphene Citrate stimulation. This is a 28-year-old woman, G2, P1 with a 4-year-old child alive, who consulted for maternity desire. She was treated with Clomiphene Citrate at 100 mg daily for five days. The presence of a quintuplet pregnancy at 8 weeks + 5 days was found by ultrasound on 29/12/2018. During the follow up of the pregnancy, she presented pre-eclampsia from 24 th week (TA 140/100 mmHg, significant proteinuria, edema of lower limbs). Methyl Dopa treatment was instituted. Tocolytic treatment with Salbumol was prescribed facing uterine contractions at 30 weeks. The patient had premature rupture of membranes at 34 weeks + 4 days, followed by uterine contractions. She had a cesarean section at the same day with the birth of five newborns alive. This is the first reported case in Burkina Faso.

First recorded spontaneous quintuplets born in Somalia: A case report

“…Compared with mothers of twins, mothers of triplets, quadruplets and quintuplets were more likely to be diagnosed with preterm premature rupture of membranes, have excessive bleeding, delivered at less than 29 weeks of gestation, and have one or more infants die. A published the first case of spontaneous quintuplet pregnancy in Africa was published in 1888 in Duffle in present-day Uganda in A. J. Mounteney-Jephson [5] . In the literature, cases of spontaneous quintuplet pregnancies have been reported in India, Pakistan, and Germany [3] , [6] .…”