“…In one study, when evaluating smoking in the sub-population of people with peripheral arterial disease, it was found that approximately 26% smoke, and as many as 79% have a smoking history, either current or former (Dunkley, et al, 2007). Smoking is a top modifiable risk factor contributing to PAD, second only to diabetes (Alexopoulos, Vlachopoulos, & Stefanadis, 2010;Conen et al, 2011;Hennrikus et al, 2010;Federman and Kravetz, 2007;Katsiki, Papadopoulou, Fachantidou, & Mikhailidis, 2013;Lu, Mackay, & Pell, 2014;Moyer, 2013;Muir, 2009;Paraskevas, Papas, Pavlidis, Bessias, & Andrikopoulos, 2008;Simmons, Steffen, & Sanders, 2012;Sontheimer, 2006;Steffen, Duprez, Boucher, Ershow, & Hirch, 2008;Verma, Prasad, Elkadi, & Chi, 2011;Watson, Watson, & Pater, 2006;Wiley, Kumar, & Vacek, 2012). Increased pack years of smoking increases the risks of developing PAD, and increases the morbidity and mortality of the diagnosis, demonstrating a dose-dependent relationship between the two (Au, Golledge, Walker, Haigh, & Nelson, 2013;Hankey, Norman, & Eikelboom, 2006;Katsiki et al, 2013;Lee et al, 2011;Paraskevas et al, 2008;Watson, Watson, & Pater, 2006).…”