Quiz Page January 2012

Forbes, Suzanne; Robert, Stefanie Christina; Martin, Joanne E.; Rajakariar, Ravindra

doi:10.1053/j.ajkd.2011.06.032

Cited by 12 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We used the title and abstract entries “endocarditis” and “ANCA or antineutrophil cytoplasmic antibody” and “renal biopsy,” which yielded 26 well documented cases (English language only). 4 – 28 We added our case to this review and compared clinical features, pathology findings, treatment, and prognosis ( Tables 1, 2 ).…”

Section: Discussionmentioning

confidence: 99%

“… 20 , 28 , 40 PR3-ANCA positivity and hypocomplementemia are more common in ANCA-positive IE than in AAV. 3 , 14 , 36 …”

Section: Discussionmentioning

confidence: 99%

“…36 Pulmonary and articular signs are less common in patients with ANCA-positive IE than in those with AAV. Splenic infarction, which is rare in AAV, occurs in 25% of patients with ANCA-positive IE, 37–39 while thrombocytopenia 14 and cerebral embolism are highly indicative of ANCA-positive IE rather than AAV. 20,28,40 PR3-ANCA positivity and hypocomplementemia are more common in ANCA-positive IE than in AAV.…”

Section: Discussionmentioning

confidence: 99%

“…ANCA-positive IE complicated by kidney injury is rare, and only 26 cases have been reported. 4–28 Little is known about the associated renal pathology, the use of immunosuppressants, and prognosis of this condition. We report here a case of IE complicated by kidney injury accompanied by the presence of PR3-ANCA.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antineutrophil cytoplasmic antibody-positive infective endocarditis complicated by acute kidney injury: a case report and literature review

Zhang

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Patients with infective endocarditis (IE) may present with multisystem disturbances resembling autoimmune diseases, such as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The kidneys are susceptible to damage in IE and AAV, which is a source of diagnostic ambiguity. Therefore, distinguishing infection from an inflammatory process is pivotal for guiding appropriate therapy. We report a 22-year-old man with IE characterized by ANCA positivity and complicated by acute kidney injury. A renal biopsy showed crescentic nephritis with tubulointerstitial lesions. However, transthoracic echocardiography and blood culture provided evidence of IE, and AAV was ruled out. Surgical intervention and antibiotic treatments were successful. We summarized previously reported cases of ANCA-positive IE that had renal biopsy data. We found that ANCA-positive IE can involve multiple organs. The representative renal pathology was crescentic nephritis, focal segmental glomerulonephritis, mesangial cell proliferation, tubular injury, and interstitial oedema. Immunofluorescence showed predominate C3 deposits. Electron microscopy showed electron-dense deposits in the subendothelial or mesangial areas. Eight patients received immunosuppressive therapy with excellent results. Repeated testing for bacterial pathogens and multiple renal biopsies may be useful for diagnosing ANCA-positive IE. With ANCA-positive IE, immunosuppressive therapy along with antibiotic treatments may be beneficial for recovery of renal function.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 20 , 28 , 40 PR3-ANCA positivity and hypocomplementemia are more common in ANCA-positive IE than in AAV. 3 , 14 , 36 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antineutrophil cytoplasmic antibody-positive infective endocarditis complicated by acute kidney injury: a case report and literature review

Zhang

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…В настоящее время с учетом актуальности проведения дифференциального диагноза между первичными АНЦАваскулитами и другими заболеваниями, сопровождающимися повышением уровня АНЦА, предложены критерии отличия таких АНЦА-васкулитов и ИЭ, положительного по АНЦА (см. таблицу) [12]. Гипокомплементемия и обнаружение пролиферативного ГН при биопсии почек подтверждает инфекционную этиологию ГН, при этом назначение антибактериальной терапии, как правило, приводит к ремиссии поражения почек при условии излечения ИЭ.…”

Section: Discussionunclassified

Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies

et al. 2017

View full text Add to dashboard Cite

Infective endocarditis (IE) may be accompanied by the production of a broad spectrum of autoantibodies, including antineutrophil cytoplasmic antibodies (ANCA). ANCA detection creates difficulties in the differential diagnosis of IE, especially in relation to kidney injury, the determination of the mechanism of which is important for choosing a treatment policy and estimating a prognosis. The paper describes a clinical case of a 57-year-old man who was found to have higher proteinase-3 (PR-3) ANCA titers along with the symptoms of anemia, purpura, and kidney injury during his hospitalization; echocardiography revealed vegetation on the aortic valve. IE was diagnosed; 2-week antibiotic therapy was ineffective; there was progressive aortic insufficiency necessitating aortic valve replacement. In the postoperative period, there was progression of renal failure and higher PR-3 ANCA titers, which made it possible to regard kidney injury as a manifestation of ANCA-associated glomerulonephritis. Intensive immunosuppressive therapy with intravenous and oral prednisolone was initiated, which showed positive effects in reducing proteinuria, erythrocyturia, serum creatinine levels, and simultaneously PR-3 ANCA titers. The paper gives the data available in the literature on the frequency of an association of IE with ANCA, the clinical features, diagnostic criteria, and treatment approaches. It discusses the mechanisms of ANCA formation in patients with IE.

show abstract

Glomerulonephritis Associated with Other Bacterial Infections

Kambham

Troxell

2017

Bacterial Infections and the Kidney

View full text Add to dashboard Cite

Quiz Page January 2012

Cited by 12 publications

References 4 publications

Antineutrophil cytoplasmic antibody-positive infective endocarditis complicated by acute kidney injury: a case report and literature review

Antineutrophil cytoplasmic antibody-positive infective endocarditis complicated by acute kidney injury: a case report and literature review

Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies

Glomerulonephritis Associated with Other Bacterial Infections

Contact Info

Product

Resources

About