Quorum-quenching activity of some Iranian medicinal plants

Moradi, Farhad; Hadi, Nahal

doi:10.1016/j.nmni.2021.100882

Cited by 18 publications

(15 citation statements)

References 13 publications

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“…The interruption of a QS signal can occur in several ways: (1) stopping the synthesis of signaling molecules; (2) inactivation or enzymatic destruction of signaling molecules, preventing accumulation to a threshold value; (3) interference with the binding of signal receptors in a bacterial cell or competition with signal molecules-receptor analogs; and (4) blocking target genes that should have been triggered by the QS signal [3,4].…”

Section: Introduction: Quorum-sensing and Quorum-quenching As Mechani...mentioning

confidence: 99%

Quorum-Sensing Inhibition by Gram-Positive Bacteria

et al. 2022

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The modern paradigm assumes that interspecies communication of microorganisms occurs through precise regulatory mechanisms. In particular, antagonism between bacteria or bacteria and fungi can be achieved by direct destruction of the targeted cells through the regulated production of antimicrobial metabolites or by controlling their adaptive mechanisms, such as the formation of biofilms. The quorum-quenching phenomenon provides such a countermeasure strategy. This review discusses quorum-sensing suppression by Gram-positive microorganisms, the underlying mechanisms of this process, and its molecular intermediates. The main focus will be on Gram-positive bacteria that have practical applications, such as starter cultures for food fermentation, probiotics, and other microorganisms of biotechnological importance. The possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria is also considered. In addition, the review provides possible practical applications for these mechanisms, such as the control of pathogens, improving the efficiency of probiotics, and plant protection.

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Section: Introduction: Quorum-sensing and Quorum-quenching As Mechani...mentioning

confidence: 99%

Quorum-Sensing Inhibition by Gram-Positive Bacteria

et al. 2022

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“…Quorum sensing inhibition was detected by a colourless, opaque, but viable halo around the disc. Methanol and ethanol were also used as a negative control 10 .…”

Section: Quorum Sensing Inhibition Assay Usingmentioning

confidence: 99%

“…Furthermore, the influence of tea extract on P. aeruginosa quorum-sensing-regulated virulence factors production, motility, and biofilm formation were also assayed 10 .…”

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confidence: 99%

Untitled

2022

IJPSR

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The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotypes, including bioluminescence, biofilm formation, drug resistance, virulence factors expression, and motility. Therefore, the inhibition of QS is considered a new promising target of antimicrobial pathways as anti-virulence compounds that can repress the gene expression of QS. Green tea is one of the most commonly consumed teas in the world. Green tea extract is also a great source of compounds like polyphenols, amino acids, enzymes, pigments, and carbohydrates. Hence, green tea has recently received considerable attention as a new source of safe and effective QS inhibitory substances. In the present study, methanolic and ethanolic various tea extracted were prepared and tested to inhibit quorum sensing mediated bacterial virulence factors such as anti-swarming, and antibiofilm potential against organism Pseudomonas aeruginosa. Quorum sensing inhibition against Chromobacterium violaceum MTCC 2656 has been carried out. The study's outcome shows that most of the methanolic and ethanolic extracts of various tea products show significantly Anti-quorum sensing Potential up to 83% swarming inhibition with Pseudomonas aeruginosa, inhibition violaceum pingment and biofilm disruption were also quite high in most of the Tea extract of ethanol and methanol. INTRODUCTION:The problem of multidrugresistant bacteria is becoming a worldwide concern nowadays. This pathogenic organism became resistant to a large range of antibiotics that possess a problem with treating various diseases 1 . Antibacterial drugs are the foremost effective of all QUICK RESPONSE CODE

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“…Globally, as of early December 2020, there were 65,257,767 million confirmed cases and 1.5 million deaths, with the highest number of cases in America, Europe, and Southeast Asia. (Khaira, 2010;Moradi and Hadi, 2021;Organization, 2020). In Southeast Asia, there were 11,023,450 cases with a death toll of 167,782.…”

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confidence: 99%

“…Indonesia as the largest contributor to cases, since January 3, 2020, confirmed 563,680 cases of COVID-19 with 17,479 deaths. (Khaira, 2010;Moradi & Hadi, 2021;Organization, 2020).…”

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confidence: 99%

The Effectiveness of High-dose N-acetylcysteine in Severe COVID-19 Patients

Hanum

Hanifa

2021

kesdok

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The study's objective was to describe the effect of using high doses of N-acetylcysteine on severe COVID-19 patients. It was evaluated from the length of stay and by monitoring the drug use data, laboratory data, and clinical data at Bhayangkara H.S Samsoeri Mertojoso Hospital Surabaya. The data was collected retrospectively from patients' Health Medical Records who got high dose N-acetylcysteine in October 2020 – February 2021, with standard therapy: antivirus (Remdesivir), antibiotics, vitamins, symptomatic and comorbid therapy, anticoagulant, and corticosteroids (Dexamethasone) as inclusion criteria, then described descriptively. The observation result confirmed that the use of a high dose of N-acetylcysteine (NAC) [1 x 1200 – 5000 mg] po/iv had effective results as seen from the patients' length of stay, which was 12 days for patients without comorbid and 14 days for patients with comorbid like diabetes and/or hypertension. The use of high dose NAC showed improvement in the patients' clinical condition that is evaluated from improved oxygen saturation by 37%. In addition, the laboratory results are shown an improvement in thorax X-ray by 69% and inflammatory markers like CRP and d-dimer by 100%. Further research that uses a prospective method is needed to get a better result on the use of high-dose NAC in patients with severe COVID-19.

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Quorum-quenching activity of some Iranian medicinal plants

Cited by 18 publications

References 13 publications

Quorum-Sensing Inhibition by Gram-Positive Bacteria

Quorum-Sensing Inhibition by Gram-Positive Bacteria

Untitled

The Effectiveness of High-dose N-acetylcysteine in Severe COVID-19 Patients

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