Quorum Quenching for Sustainable Environment: Biology, Mechanisms, and Applications

Maddela, Naga Raju; Cruzatty, Luz García; Leal-Alvarado, Daniel Alfredo; Olaya, Jessenia Castro; Chakraborty, Sagnik; Mukherjee, Anupam

doi:10.1007/978-981-15-2679-4_4

Cited by 6 publications

(2 citation statements)

References 189 publications

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“…The QQ controls various virulence factors such as sporulation, biofilm formation, enzyme production, motility, pigment production, flagella, and pili 40 . Also, biofilm formation is the main problem that makes most diseases, such as oral cavities and cystic fibrosis, hardly curing 41 .…”

Section: Quorum Quenching In Medical Applicationmentioning

confidence: 99%

The Role of Quorum Quenching in Medical Application

Mohammad,

Waleed Hadi

2024

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The attempts are continuing in the various fields of life sciences to resolve a big problem, which is the ability of bacteria to cause pathogenicity for humans, animals, and plants, whether by chemical or biological methods and in ways that are hoped to be safe. Among these attempts, the control of the Quorum Sensing (QS) mechanism that occurs naturally in bacteria under certain conditions helps to increase the virulence of bacteria, starting from its ability to adhere and form a biofilm. Then, the tissues are invaded with various enzymes according to the tissue type, increasing antibiotic resistance. Therefore, the idea came to solve these problems through a mechanism opposite to the Quorum Quenching (QQ), which lies in the investigation of substances that can disrupt the QS pathway, whether at the molecular level or the physiological level, as well as benefiting from different organisms (Prokaryotes or Eukaryotes) that live in the same environment and produce substances that inhibit bacterial signaling molecules. Lastly, the discovery of varying novel QQ agents from extreme environmental bacteria will be most interesting in the future. Keywords: Quorum sensing, quorum quenching, acyl homoserine lactones, medical application

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Section: Quorum Quenching In Medical Applicationmentioning

confidence: 99%

The Role of Quorum Quenching in Medical Application

Mohammad,

Waleed Hadi

2024

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“…The issues of creating easily reproducible artificial consortia based on the use of well-studied cell strains with stable, safe, and efficient functioning, in case of their application in practice for the sustainable development of ecological systems, are of great scientific and practical importance since they are components of the rational use of biological resources and actively developing synthetic biology [ 7 , 8 ]. The rational selection of microbial candidates and the experimental confirmation of the choice are often the drivers of such a process [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“Unity and Struggle of Opposites” as a Basis for the Functioning of Synthetic Bacterial Immobilized Consortium That Continuously Degrades Organophosphorus Pesticides

et al. 2022

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This work was aimed at the development of an immobilized artificial consortium (IMAC) based on microorganisms belonging to the Gram-positive and Gram-negative bacterial cells capable of jointly carrying out the rapid and effective degradation of different organophosphorus pesticides (OPPs): paraoxon, parathion, methyl parathion, diazinon, chlorpyrifos, malathion, dimethoate, and demeton-S-methyl. A cryogel of poly(vinyl alcohol) was applied as a carrier for the IMAC. After a selection was made between several candidates of the genera Rhodococcus and Pseudomonas, the required combination of two cultures (P. esterophilus and R. ruber) was found. A further change in the ratio between the biomass of the cells inside the granules of IMAC, increasing the packing density of cells inside the same granules and decreasing the size of the granules with IMAC, gave a 225% improvement in the degradation activity of the cell combination. The increase in the velocity and the OPP degradation degree was 4.5 and 16 times greater than the individual P. esterophilus and R. ruber cells, respectively. Multiple uses of the obtained IMAC were demonstrated. The increase in IMAC lactonase activity confirmed the role of the cell quorum in the action efficiency of the synthetic biosystem. The co-inclusion of natural strains in a carrier during immobilization strengthened the IMAC activities without the genetic enhancement of the cells.

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