PurposeThis study examines how technological innovation (TECIN) and human capital development (HCD) combine to impact industrial productivity (INPR) and competitiveness in Africa.Design/methodology/approachThe study used secondary data covering the period from 1996 to 2021 on 36 African countries, in a panel data framework of fixed effect and generalized method of moments techniques.FindingsThe study found that while TECIN negatively affected INPR in Africa, HCD exerted a strong positive influence. The interaction of TECIN and HCD showed a joint positive impact on INPR, emphasizing the role of human capital in mitigating transitional productivity loss tied to new technology assimilation. The results also showed positive individual and combined effects of TECIN and HCD on industrial competitiveness in Africa.Practical implicationsThe findings therefore compel the need for implementation of policies that can simultaneously advance TECIN and strengthen HCD for sustainable industrial development in Africa. Governments in African countries need to allocate more resources to research and development to foster home-grown technologies, revamp educational curricula to align with industry needs and emphasize practical skills training, and facilitate technology transfer partnerships to enhance technological capabilities and INPR.Originality/valueAlthough previous studies acknowledge the importance of TECIN and HCD for enhancing INPR and competitiveness in Africa, there is a noticeable lack of comprehensive studies that investigated the interplay between TECIN and HCD for industrialization gains.