R-phycocyanin from porphyra haitanensis influences drosophila melanogaster lifespan in a sex-specific manner

Lactobacillus reuteri's multifaceted role in mitigating ionizing radiation-induced injury inDrosophila melanogaster

“…64 When AMPK is specifically activated in Drosophila , it can delay aging and prolong life. 65 However, it is important to note that this correlation may not always be observed during hunger. The regulation of AMPK in different cells and tissues can have varied effects on lifespan.…”

“…Recently, it has been shown that specific activation of AMPK delays senescence and extends the lifespan in Drosophila. 65 However, as in mammals, the regulation of AMPK function extends beyond metabolic rate and lipid metabolism. Indeed, experiments using Drosophila suggest that AMPK may play a protective role in lifespan and neurodegeneration.…”

“…Overexpression of AMPK in neurons has been found to shorten the lifespan of starved transgenic animals, while overexpression of dominant negative regulation of AMPK in neuroendocrine cells has been shown to prolong the lifespan of starved transgenic animals. 65,66 Additionally, tissue-specific regulation of AMPK activity may have different effects on lifespan. 67,68 Not only does AMPKα regulate energy consumption, 69 but it also plays a role in regulating mitochondrial biosynthesis and dynamics through NAD+ metabolism.…”