R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini

Opisthorchiasis due to the liver fluke Opisthorchis felineus is highly prevalent in rural regions of Western Siberia, causing severe liver and bile duct maladies. Praziquantel administered as a three-dose regimen is the only drug used to treat O. felineus -infected individuals. A simpler single-dose treatment might serve as an alternative. The aim of this study was to compare the pharmacokinetic (PK) properties of single, ascending doses of praziquantel compared to multiple dosing in patients infected with O. felineus to contribute to updated treatment guidelines.

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Modeling the Double Peak Phenomenon in Drug Absorption Kinetics: The Case of Amisulpride

Kousovista

Karali

Karalis

2023

BioMedInformatics

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An interesting issue observed in some drugs is the “double peak phenomenon” (DPP). In DPP, the concentration-time (C-t) profile does not follow the usual shape but climbs to a peak and then begins to degrade before rising again to a second peak. Such a phenomenon is observed in the case of amisulpride, which is a second-generation antipsychotic. The aim of this study was to develop a model for the description of double peaks in amisulpride after oral administration. Amisulpride plasma C-t data were obtained from a 2 × 2 crossover bioequivalence study in 24 healthy adult subjects. A nonlinear mixed-effects modeling approach was applied in order to perform the analysis. Participants’ characteristics, such as demographics (e.g., body weight, gender, etc.), have also been investigated. A model for describing the double peak phenomenon was successfully developed. Simulations were run using this model to investigate the impact of significant covariates and recommend appropriate dosage regimens. For comparison purposes and to investigate the suitability of our developed model for describing the double peak phenomenon, modeling of previously published population pharmacokinetic models was also applied to the C-t data of this study.

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R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini

Cited by 3 publications

References 65 publications

Current drug strategies for the treatment and control of schistosomiasis

Current drug strategies for the treatment and control of schistosomiasis

Pharmacokinetics of Ascending Doses of Praziquantel in Adults Infected with Opisthorchis felineus in Western Siberia, Russian Federation

Modeling the Double Peak Phenomenon in Drug Absorption Kinetics: The Case of Amisulpride

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