2014
DOI: 10.1016/j.neuroscience.2014.07.010
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R-Ras contributes to LTP and contextual discrimination

Abstract: The ability to discriminate between closely related contexts is a specific form of hippocampal-dependent learning that may be impaired in certain neurodegenerative disorders such as Alzheimer's and Down Syndrome. However, signaling pathways regulating this form of learning are poorly understood. Previous studies have shown that the calcium-dependent exchange factor Ras-GRF1, an activator of Rac, Ras and R-Ras GTPases, is important for this form of learning and memory. Moreover, the ability to discriminate cont… Show more

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Cited by 10 publications
(9 citation statements)
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“…Genes up-regulated exclusively at the level of translational efficiency were related to Aβ production and disease. Examples include SERF2, a positive regulator of amyloid protein aggregation [104,105], and HRAS2, an apparent AD biomarker that is stimulated by Aβ and produces a reduction in LTP [78]. Some transcriptionally down-regulated genes confirmed what was expected from previous reports.…”
Section: Tg2576 Mice Differentially Express Genes Associated With App Metabolismsupporting
confidence: 73%
See 1 more Smart Citation
“…Genes up-regulated exclusively at the level of translational efficiency were related to Aβ production and disease. Examples include SERF2, a positive regulator of amyloid protein aggregation [104,105], and HRAS2, an apparent AD biomarker that is stimulated by Aβ and produces a reduction in LTP [78]. Some transcriptionally down-regulated genes confirmed what was expected from previous reports.…”
Section: Tg2576 Mice Differentially Express Genes Associated With App Metabolismsupporting
confidence: 73%
“…Some of these genes are associated with protective or beneficial functions. For example, FRMD4A, PPARG and RRAS2 have been shown to reduce high levels of Aβ production [77][78][79][80], while ADAM12, MID1 and LDLRAD3 influence Aβ production or neurotoxicity [68,81,82].…”
Section: Regulated Genes In Cvn Mice Reveal a Signature Of Microglia Responding To Aβmentioning
confidence: 99%
“…A similar combination of an impairment of context discrimination and modified LTP in the CA1 region in vitro has also been observed in other studies. For instance, inhibition of the Ras-GRF1 pathway in the CA1 region modulated LTP and context discrimination ( Jin et al 2013 ; Darcy et al 2014 ). Thus, the present study uncovers a contribution of HSs for hippocampal LTP and context discrimination and also supports the notion that the CA1 region is involved in context discrimination ( Place et al 2012 ; Czerniawski and Guzowski 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…More recent studies have also described similar combinations of impairment of context discrimination and altered LTP in the CA1 region (Darcy et al, 2014;Minge et al, 2017). Moreover, one study that linked cognitive de cits during acute neuroin ammation also supported that the CA1 region is involved in context discrimination (Czerniawski & Guzowski, 2014).…”
Section: Discussionmentioning
confidence: 79%