We consider operator-valued boundary value problems in (0, 2π) n with periodic or, more generally, ν-periodic boundary conditions. Using the concept of discrete vector-valued Fourier multipliers, we give equivalent conditions for the unique solvability of the boundary value problem. As an application, we study vector-valued parabolic initial boundary value problems in cylindrical domains (0, 2π) n × V with ν-periodic boundary conditions in the cylindrical directions. We show that under suitable assumptions on the coefficients, we obtain maximal L q -regularity for such problems.2010 Mathematics Subject Classification. 35J40, 35K46.