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Abstract

Three organotin complexes were successfully synthesized via condensation reactions of cephalexin) ligand (and di-organotin (IV) complexes in the presence of sodium hydroxide. Infrared, nuclear magnetic resonance (1H, 13C, 119Sn NMR) and elemental analyses were used to characterize the produced compounds. Based on the spectrum observations octahedral geometry was proposed for the complexes synthesized. This study looked at the antioxidant activity of tin (IV) compounds using two methods free radical scavenging activity (DPPH) and the CUPRAC method. Dioganotin (IV)cephalexin complexes showed higher antioxidant activity than ligands due to the metal moiety, while complex (Me2SnL2) showed higher antioxidant activity than other complexes.

Enhancement of Photostabilization of Poly(Vinyl Chloride) in the Presence of Tin–Cephalexin Complexes

“…Reactions of excess cephalexin (2 mole equivalent) and disubstituted tin dichloride (diphenyltin dichloride, dibutyltin dichloride, and dimethyltin dichloride) in methanol (MeOH) under reflux for 5 h gave 1 – 3 . The spectroscopic and analytical data of 1 − 3 agreed with those reported [ 43 ].…”

“…Tin–cephalexin complexes 1–3 ( Scheme 1 ) were synthesized in high yields (78−98%) employing a reported procedure [ 43 ]. Reactions of excess cephalexin (2 mole equivalent) and disubstituted tin dichloride (diphenyltin dichloride, dibutyltin dichloride, and dimethyltin dichloride) in methanol (MeOH) under reflux for 5 h gave 1 – 3 .…”

Synthesis and Identification of Triorganotin (IV)-Tyrosine Complexes and Study Their Applications as Antioxidant by DPPH and CUPRAC Methods.

“…Consequently, there is an increasing interest in producing new substances that have antioxidant activity. The process of adding a metal ion to an organic molecule to create a coordination complex, which can have unique biological and chemical properties, is one method of creating such molecules [1][2][3][4] Due to the diverse applications of organotin compounds 5 , a class of organometallic compounds, in various fields such as agriculture, medicine, and industry, they have been widely studied [6][7][8][9] One of the most common organotin(IV) compounds are tri butyl, triphenyl and methyl-tin(IV) compounds that have been synthesized and studied 10 . These compounds have been found to possess antioxidant activity, in addition to their antifungal, antibacterial, and anticancer activities.…”