Untitled

Abstract

Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats. To further explore the mechanism of action of arjunolic acid, antiplatelet activity, anticoagulant assays, electrocardiographic changes, serum marker enzymes, antioxidant status, lipid peroxide and myeloperoxidase (MPO) have been measured and the results are compared with a potent cardioprotective drug, acetyl salicylic acid (ASA). Administration of isoproterenol produces electrocardiographic changes such as decreased R amplitude and increased ST segment elevation and has resulted in an increase in serum marker enzyme levels as well as a decrease in enzymatic and nonenzymatic antioxidant levels. Arjunolic acid at an effective dosage of 15 mg/kg body wt. (pre and post treatment), when administered intraperitoneally (i.p.), effects a decrease in serum enzyme levels and the electrocardiographic changes get restored towards normalcy. Arjunolic acid treatment is also shown to prevent the decrease in the levels of superoxide dismutase, catalase, glutathione peroxidase, ceruloplasmin, alpha-tocopherol, reduced glutathione (GSH), ascorbic acid, lipid peroxide, MPO and the cardioprotection is confirmed by the histopathological studies. This study shows that the cardioprotection of arjunolic acid pre and post treatment could possibly be due to the protective effect against the damage caused by myocardial necrosis.

Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.

“…Similarly, the crude extract from the branches furnished the same fractions as those indicated above, but only the hexane fraction has been studied so far, furnishing the triterpene arjunolic acid (5). All the isolated compounds were identified on the basis of analyses of melting point, IR spectra, 1 H and 13 C NMR spectra which are identical to those reported in the literature. Compounds (1-4) were confirmed by co-TLC with authentic samples.…”

“…[7][8][9] Triterpene arjunolic acid (5) was previously isolated from other plants of the genus Myrtaceae, including Eugenia florida 10 and Melaleuca alternifolia, 11 and a few biological properties are cited in the literature. [12][13][14][15][16] Table 1 shows the results of analgesic activity of extract and fractions from M. tomentosa (leaves and branches) against the writhing test, administered intraperitoneally, at 10 mg/kg, which indicates that some of them exhibit pronounced effects. The most promising result was demonstrated by dichloromethane fraction, which caused inhibition of 91.1 ± 3.2%, whereas the reference drugs acetyl salicylic acid and indomethacin, caused inhibition of just 18.0 ± 4.0 and 45.7 ± 2.0%, respectively, in the same model and dose.…”

“…Spots were visualized by short-wave UV light, sulfuric anisaldehyde and FeCl 3 reagents. The identification of isolated compounds was performed by analyses of melting point, IR spectra, 1 H and 13 C NMR spectra as well as the comparison of the physical data with those reported in the literature. The molecular structures of compounds (1-4) were confirmed by co-TLC, using authentic samples.…”

Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: anti-inflammatory and anticholinesterasic activities

“…Studies on the neuroprotective action of asiatic acid (2α, 3β, 23-trihydroxyursan-12-en-28-oic acid, 3) and derivatives showed that free C(28)-CO 2 H and the triol groups are very important against (Aβ)-induced neurotoxicity. 19 The small structural difference between arjunolic (1) and asiatic (3) acids, together with literature data on the oxidative stress reduction property of both acids 20 and our antiinflammatory and anticholinesterasic results of arjunolic acid, suggest these compounds as promising models for the development of innovative multi-functional drugs for AD treatment. 21 As "Mofumbo" root major compound is arjunolic acid, followed by small amounts of monosaccharide and fatty acids, it can be a powerful candidate for the development of a new phytomedicine for neurodegenerative disorders.…”

Two New Oleanane Triterpene Glycosides from the Bark of Terminalia arjuna

“…Its stem bark has found extensive application in Indian system of medicine as a cardiac tonic with particular efficacy against heart failure, ischaemic cardiomyopathy, artherosclerosis and coronary artery ailments [1]. The cardioprotective activities of the bark have also been substantiated by various pharmacological evaluations and clinical trials [2]. A number of terpenoid saponins (arjunic acid, arjunolic acid, arjungenin, arjunglycosides), flavonoids (arjunone, arjunolone, luteolin), gallic acid, ellagic acid and phytosterols have been isolated from the bark [3], but the issue of active principles and the mechanism of therapeutic activity of T. arjuna remain to be elucidated.…”