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Abdullin, I. F.; Chernysheva, N. N.; Будников, Г. К.

doi:10.1023/a:1016877926725

Cited by 4 publications

(1 citation statement)

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“…Recently, electrochemical methods have been applied to determine procaine with high sensitivity. For example, polarography [34][35][36], coulometric titration [37] and potentiometric titration [38], ionselective electrode [39], and voltammetric method based on modified electrode [40][41][42] were employed to detect procaine or PABA. However, the electrochemical simultaneous determination of procaine and PABA has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous and sensitive determination of procaine and its metabolite for pharmaceutical quality control and pharmacokinetic research by using a graphite paste electrode

Liu

Wang

Chen

et al. 2011

J Solid State Electrochem

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A simple, rapid, sensitive, and accurate method for simultaneous electrochemical determination of procaine and its metabolite (p-aminobenzoic acid, PABA) for pharmaceutical quality control and pharmacokinetic research was developed using a graphite paste electrode. The differential pulse voltammetric results revealed that procaine and p-aminobenzoic acid, respectively, showed well-defined anodic oxidation peaks on a carbon paste electrode with a current peak separation of 155 mV at a scan rate of 100 mV s −1 . This well separation of the current peaks for these two compounds in voltammetry enables us to simultaneously determine them. Good linearity (r> 0.998) between oxidation peak current and concentration was obtained in the range of 5.0×10 −7 -5.0×10 −5 M for procaine and 5.0×10 −7 -2.0×10 −5 M for PABA in pH 4.50 acetate buffer solution. The detection limit for both analytes is 5×10 −8 M (S/N=3:1). The present voltammetric method has been successfully used to determine trace p-aminobenzoic acid in procaine hydrochloride injection and procaine in plasma with a linear relationship of current to its concentration ranging from 1.0×10 −6 to 5.0×10 −5 M (correlation coefficient of 0.9981) with a low detection limit of 5.0× 10 −7 M (S/N=3:1). This validated method is promising to the study of pharmacokinetics in Sprague-Dawley rat and rabbit plasma after an intravenous administration of procaine hydrochloride injection.

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