2021
DOI: 10.1016/j.cub.2021.04.075
|View full text |Cite
|
Sign up to set email alerts
|

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
26
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 35 publications
(28 citation statements)
references
References 61 publications
1
26
1
Order By: Relevance
“…It is unclear why eGFP-KIF13B localizes to cilia in hTERT-RPE1 cells and not IMCD3 cells, but the former possess a deep ciliary pocket whereas the latter do not (Ghossoub et al, 2011), which might influence the ability of KIF13B to enter cilia. Similarly, RAB34 was recently shown to function specifically at cilia in cells with a ciliary pocket (Ganga et al, 2021, Stuck et al, 2021).…”
Section: Resultsmentioning
confidence: 88%
“…It is unclear why eGFP-KIF13B localizes to cilia in hTERT-RPE1 cells and not IMCD3 cells, but the former possess a deep ciliary pocket whereas the latter do not (Ghossoub et al, 2011), which might influence the ability of KIF13B to enter cilia. Similarly, RAB34 was recently shown to function specifically at cilia in cells with a ciliary pocket (Ganga et al, 2021, Stuck et al, 2021).…”
Section: Resultsmentioning
confidence: 88%
“…To begin with, cilia formation, which involves assembly and extensive tubulation of membrane‐bound vesicles around the mother centriole (Sorokin, 1962), needs phosphatidylinositol‐3‐phosphate (PI(3)P) (Franco et al, 2014). Although it is still unclear how lipid dynamics facilitate the formation and flattening of lipid vesicles, the PI(3)P enrichment at the periciliary vesicle indicates that the phosphoinositide formation could recruit the small GTPase Rab8 and its effectors, such as the Bin‐Amphiphysin‐RVS (BAR) domain‐containing proteins PASCIN1/2 and EHD1/3 (Insinna et al, 2019; Q. Lu, Insinna, et al, 2015) and Rab34 (Ganga et al, 2021; Stuck et al, 2021). The BAR‐domain proteins are recruited to the membrane rich in negatively charged lipid head groups such as the phosphatidylcholine (PC), phosphatidylserine (PS) and phosphoinositides (Nishimura et al, 2018) through the small GTPases Rab8 and Rab11, which play a significant role in the cilia assembly (Westlake et al, 2011; Yoshimura et al, 2007).…”
Section: Ciliary Lipids—composition and Local Modificationmentioning
confidence: 99%
“…The BAR-domain proteins are recruited to the membrane rich in negatively charged lipid head groups such as the phosphatidylcholine (PC), phosphatidylserine (PS) and phosphoinositides (Nishimura et al, 2018) through the small GTPases Rab8 and Rab11, which play a significant role in the cilia assembly (Westlake et al, 2011;Yoshimura et al, 2007). A recent study further implicated Rab34 in flattening the ciliary vesicles once they associate with the distal appendage (Ganga et al, 2021;Stuck et al, 2021).…”
Section: Phosphoinositidesmentioning
confidence: 99%
“…Presently, more than 60 RABs have been identified in humans (Anand et al, 2020). Deregulation of RABs has been reported in several diseases, including various cancers (Sun et al, 2018;Ganga et al, 2021). They function either as an oncogene or tumor suppressors depending on cancer types.…”
Section: Introductionmentioning
confidence: 99%