2002
DOI: 10.1074/jbc.m109022200
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Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion

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Cited by 129 publications
(133 citation statements)
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“…Reports of apparent caveolar egress of ␤2AR after agonist stimulation in cultured cardiomyocytes (29), compared with our observation of caveolar targeting of ␤2AR after isoproterenol stimulation in intact hearts, are more readily explained. The prolonged (30-min) period of isoproterenol exposure in the tissue culture study likely induced receptor internalization (36), explaining the loss of receptors from caveolae.…”
Section: Discussionmentioning
confidence: 99%
“…Reports of apparent caveolar egress of ␤2AR after agonist stimulation in cultured cardiomyocytes (29), compared with our observation of caveolar targeting of ␤2AR after isoproterenol stimulation in intact hearts, are more readily explained. The prolonged (30-min) period of isoproterenol exposure in the tissue culture study likely induced receptor internalization (36), explaining the loss of receptors from caveolae.…”
Section: Discussionmentioning
confidence: 99%
“…For example, Rab5 regulates the endocytic trafficking from the plasma membrane to the endosome of G protein-coupled receptors including ␤ 2 -AR, AT1R, dopamine D 2 , endothelin, -opioid, m4 muscarinic acetylcholine, and neurokinin 1 receptors (38,(47)(48)(49)(50). Rab4 and Rab11 may control the recycling of internalized ␤ 2 -AR and AT1R from the endosome to the plasma membrane (38,50,51). Rab7 may be involved in the targeting of G protein-coupled receptors to the lysosome for degradation (51).…”
Section: Discussionmentioning
confidence: 99%
“…Most studies on the roles of Rab GTPases in the intracellular trafficking of GPCRs have been focused on the events involved in the internalization, degradation, and transport between the ER and the Golgi of the receptors (22)(23)(24). In contrast, much less is known about the involvement of Rab GTPases in GPCR export from the Golgi to the plasma membrane.…”
mentioning
confidence: 99%