Rabbit cingulate cortex: Cytoarchitecture, physiological border with visual cortex, and afferent cortical connections of visual, motor, postsubicular, and intracingulate origin

Vogt, Brent A.; Sikes, Robert W.; Swadlow, Harvey A.; Weyand, Theodore G.

doi:10.1002/cne.902480106

Cited by 95 publications

(49 citation statements)

References 39 publications

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“…The cytoarchitecture of cingulate cortex has been reported for Nissl-stained material (Vogt et al, 1986) and the first report of midcingulate cortex (MCC) in the rabbit made with Nisslstained preparations (Vogt, 1993). The ACC had the greatest density of cutaneous nociceptive neurons in rabbit and MCC is the most active region during noxious stimulation in human (Vogt et al, 2003).…”

Section: Histological Preparations and Localization Of Electrodes Armentioning

confidence: 97%

“…Nociceptive afferents to ACC do not appear to arise from the anterior insula because there are no such projections in rabbit (Vogt et al, 1986), they are weak in monkey (Mesulam and Mufson, 1982;Vogt and Pandya, 1987), and undercut lesions that remove cortical inputs to ACC do not block nociception , while thalamic lidocaine does. Thus, the thalamus is a source of nociceptive cingulate inputs during premotor functions beyond simple emotions and unpleasantness.…”

Section: Source and Latency Of Visceral Nociceptive Signalmentioning

confidence: 99%

“…These projections regulate the descending noxious inhibitory system (Toda, 1992;Senapati et al, 2005). Third, layer II-III neurons emit corticocortical projections (Bassett and Berger, 1982;Vogt et al, 1986) and suggests further integration preceding descending outputs. Monconduit et al (2007) showed that somatosensory layer VI gates the flow of noxious information into the cortex.…”

Section: Role Of Superficial and Deep Layers In Nociceptionmentioning

confidence: 99%

“…Rabbit neurons are large and easily isolated for recording and its ACC, MCC, and retrosplenial cortex are well differentiated (Vogt et al, 1986;Vogt, 1993). Here the distribution of cingulate visceronociceptive neurons was evaluated along with the structure of each nociceptive layer and their excitatory and inhibitory characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Sikes

Vogt

2008

Pain

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Human imaging localizes most visceral nociceptive responses to anterior cingulate cortex (ACC), however, imaging in conscious subjects cannot completely control anticipatory and reflexive activity or resolve neuron activity. This study overcame these shortcomings by recording individual neuron responses in 12 anesthetized and paralyzed rabbits to define the visceronociceptive response pattern by region and layer. Balloon distension was applied to the colon at innocuous (15 mmHg) or noxious (60 mmHg) intensities, and innocuous and noxious mechanical, thermal and electrical stimuli were applied to the skin. Simultaneous recording from multiple regions assured differences were not due to anesthesia and neuron responses were resolved by spike sorting using principal components analysis. Of the total 346 neurons, 48% were nociceptive; responding to noxious levels of visceral or cutaneous stimulation, or both. Visceronociceptive neurons were most frequent in ACC (39%) and midcingulate cortex (MCC, 36%) and infrequent in retrosplenial cortex (RSC, 12%). In contrast, cutaneous nociceptive units were higher in MCC (MCC, 43%; ACC, 32%; RSC, 23%). Visceralspecific neurons were proportionately more frequent in ACC (37%), while cutaneous-specific units predominated in RSC (62.5%). Visceral nociceptive response durations were longer than those for cutaneous responses. Postmortem analysis of electrode tracks confirmed regional designations, and laminar analysis found inhibitory responses mainly in superficial layers and excitatory in deep layers. Thus, cingulate visceral nociception extends beyond ACC, this is the first report of nociceptive activity in RSC including nociceptive cutaneous responses, and these regional differences require a new model of cingulate nociceptive processing.

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Section: Histological Preparations and Localization Of Electrodes Armentioning

confidence: 97%

Section: Source and Latency Of Visceral Nociceptive Signalmentioning

confidence: 99%

Section: Role Of Superficial and Deep Layers In Nociceptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Sikes

Vogt

2008

Pain

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“…van Groen and Wyss (1988) reported projections from all parts of the anterior thalamic nuclei to the superficial layers of postsubiculum. In addition, retrosplenial cortex sends fibers to layers I and III of the postsubiculum in the rat (Vogt and Miller, 1983), but to layers I and V of the postsubiculum in the rabbit (Vogt et al, 1986). Visual areas 17 and 18 have an input into postsubicular layers I and III (Vogt and Miller, 1983).…”

Section: Anatomy Of Postsubiculummentioning

confidence: 99%

Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis

1990

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This paper is a study of the behavioral and spatial firing correlates of neurons in the rat postsubiculum. Recordings were made from postsubicular neurons as rats moved freely throughout a cylindrical chamber, where the major cue for orientation was a white card taped to the inside wall. An automatic video/computer system monitored cell discharge while simultaneously tracking the position of 2 colored light emitting diodes (LEDs) secured to the animal's head. The animal's location was calculated from the position of one of the LEDs and head direction in the horizontal plane calculated from the relative positions of the 2 LEDs. Approximately 26% of the cells were classified as head-direction cells because they discharged as a function of the animal's head direction in the horizontal plane, independent of the animal's behavior, location, or trunk position. For each head-direction cell, vectors drawn in the direction of maximal firing were parallel throughout the recording chamber and did not converge toward a single point. Plots of firing rate versus head direction showed that each firing-rate/head-direction function was adequately described by a triangular function. Each cell's maximum firing rate occurred at only one (the preferred) head direction; firing rates at head directions on either side of the preferred direction decreased linearly with angular deviation from the preferred direction. Results from 24 head-direction cells in 7 animals showed an equal distribution of preferred firing directions over a 360 degrees angle. The peak firing rate of head- direction cells varied from 5 to 115 spikes/sec (mean: 35). The range of head-direction angles over which discharge was elevated (directional firing range) was usually about 90 degrees, with little, if any, discharge at head directions outside this range. Quantitative analysis showed the location of the animal within the cylinder had minimal effect on directional cell firing. For each head-direction cell, the preferred direction, peak firing rate, and directional firing range remained stable for days. These results identify a new cell type that signals the animal's head direction in its environment.

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Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat

et al. 1996

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Immunohistochemical detection of the protein product (Fos) of the c-fos immediate early gene was used to study neuronal activation in the rostral pons and midbrain of halothane-anesthetised rats following noxious deep somatic or noxious visceral stimulation. In animals exposed only to halothane anesthesia, Fos-like immunoreactive (IR) neurons were located in the midbrain periaqueductal gray matter, tectum, and parabrachial nucleus. Following noxious stimulation of hindlimb muscle, knee joint, vagal cardiopulmonary, or peritoneal nociceptors, there was, compared to halothane-only animals, a significant increase in the numbers of Fos-like (IR) cells in the caudal ventrolateral periaqueductal gray and the intermediate gray lamina of the superior colliculus. Given the general agreement that increased Fos expression is a consequence of increased neuronal activity, the finding that a range of noxious deep somatic and noxious visceral stimuli evoked increased neuronal activity in a discrete, caudal ventrolateral periaqueductal gray region is consistent with previous suggestions that this region is an integrator of deep noxious evoked reactions. The noxious deep somatic and noxious visceral manipulations also evoked, compared to halothane-only animals, reductions in the numbers of Fos-like IR cells in the stratum opticum of the superior colliculus and the unlaminated portion of the external subnucleus of the inferior colliculus. To our knowledge this is the first report of reductions in Fos-expression in the tectum evoked by noxious stimulation. In separate experiments, the effects of noxious deep somatic and noxious visceral manipulations on arterial pressure and heart rate were measured. The noxious visceral manipulations evoked substantial and sustained falls in arterial pressure (15-45 mmHg), and heart rate (75-100 bpm), whereas the depressor and bradycardiac effects of the noxious deep somatic manipulations were weaker, not as sustained, or entirely absent. As similar distributions and numbers of both increased and decreased Fos-like IR cells were observed after each of the deep noxious manipulations, it follows that the deep noxious evoked increases and decreases in Fos expression were not secondary to the evoked depressor or bradycardiac effects.

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Rabbit cingulate cortex: Cytoarchitecture, physiological border with visual cortex, and afferent cortical connections of visual, motor, postsubicular, and intracingulate origin

Cited by 95 publications

References 39 publications

Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex

Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis

Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat

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