Rabbit Respiratory System: Clinical Anatomy, Physiology and Disease

A Single Primary Site Obstruction May Lead to Sleep-Disordered Breathing in Multiple Sites

“…In other words, the mechanism of the palate collapse along with the tongue base in this model may be explained by fluid dynamics. 19 Therefore, it might not be feasible to directly extrapolate these findings to the human airway during OSA. Therefore, the retropalatal air pressure decreases with palatal collapse as the air passes through the constricted paralyzed tongue base.…”

Establishment of a Rabbit Model of Obstructive Sleep Apnea by Paralyzing the Genioglossus

“…In contrast to humans, rabbits are obligate nasal breathers due to their epiglottis positioned rostrally to the soft palate. 12 Several studies in animals and humans have shown that stimulation of the hypoglossal nerve or direct stimulation of the genioglossus could widen the upper airway space in the retroglossal area and improve sleep-related breathing disorder. 13,14 Thus, in spite of anatomical differences of the upper airway, we assumed that collapse of the airway around the tongue base by genioglossus paralysis would cause OSA in rabbits.…”

Immunogenicity of recombinant outer membrane porin protein and protective efficacy against lethal challenge with Bordetella bronchiseptica in rabbits

“…Occasionally, B. bronchiseptica causes infections in infants, people who are in close contact with animals, or immunologically compromised individuals (Woolfrey and Moody 1991). Bordetella bronchiseptica often colonizes the rabbit respiratory tract, such as the nostrils and bronchi, and is considered as a common pathogen or susceptible factor for Pasteurella multocida infection (Mattoo and Cherry 2005;Johnson-Delaney and Orosz 2011). Antibiotics are still the main treatment for B. bronchiseptica infections (Mattoo and Cherry 2005).…”