Rabbit Snout Gro+wth: Effect of Injury to Septovomeral Region

Wexler, Manuel R.; Sarnat, Bernard G.

doi:10.1001/archotol.1961.00740030312013

Cited by 60 publications

(28 citation statements)

References 3 publications

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“…The results of our analysis indicate that the developmental relationship between the nasal septum and premaxilla, as one component of midfacial growth, contributes to variation in adult facial length (e.g., Wexler and Sarnat, 1961;Sarnat and Wexler, 1966;Mooney et al, 1989;Wealthall and Herring, 2006). Our first hypothesis that facial growth restriction has no effect on the length of the nasal septum was indirectly supported by this analysis.…”

Section: Discussionsupporting

confidence: 61%

“…Although the nasal septal cartilage and vomer have different embryologic origins, previous research has documented a highly integrated relationship between these structures. For example, as with surgical extirpation of the nasal septal cartilage, extirpation of the vomer and interruption of the vomerpremaxillary suture in long-snouted animals also reduces the anterior growth of the maxilla and premaxilla (Wexler and Sarnat, 1961;Latham et al, 1975;Wada et al, 1980). A similar result has also been documented in humans (Friede, 1978;Freide and Morgan, 1976).…”

Section: Methodsmentioning

confidence: 99%

“…A number of experimental studies have emphasized the importance of the nasal septum in facial growth largely through surgical extirpation of all or part of the nasal septum, which typically results in a deficiency in anteroposterior growth of the maxilla and premaxilla (e.g., Wexler and Sarnat, 1961;Ohyama, 1969;Riesenfeld, 1970;Latham et al, 1975;Wada et al, 1980;Siegel and Sadler, 1981;Squier et al, 1985). Experimental work by Sarnat and Wexler (e.g., Wexler and Sarnat, 1961;Wexler, 1966, 1967) as well as RhysEvans and Brain (1981), for example, found that resection of the nasal septal cartilage in a rabbit model resulted in a reduction in the length of the snout including the premaxilla, nasal bones, and palate.…”

mentioning

confidence: 99%

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Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Holton

Franciscus

Marshall

et al. 2010

The Anatomical Record

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The influence of the chondrocranium in craniofacial development and its role in the reduction of facial size and projection in the genus Homo is incompletely understood. As one component of the chondrocranium, the nasal septum has been argued to play a significant role in human midfacial growth, particularly with respect to its interaction with the premaxilla during prenatal and early postnatal development. Thus, understanding the precise role of nasal septal growth on the facial skeleton is potentially informative with respect to the evolutionary change in craniofacial form. In this study, we assessed the integrative effects of the nasal septum and premaxilla by experimentally reducing facial length in Sus scrofa via circummaxillary suture fixation. Following from the nasal septal-traction model, we tested the following hypotheses: (1) facial growth restriction produces no change in nasal septum length; and (2) restriction of facial length produces compensatory premaxillary growth due to continued nasal septal growth. With respect to hypothesis 1, we found no significant differences in septum length (using the vomer as a proxy) in our experimental (n ¼ 10), control (n ¼ 9) and surgical sham (n ¼ 9) trial groups. With respect to hypothesis 2, the experimental group exhibited a significant increase in premaxilla length. Our hypotheses were further supported by multivariate geometric morphometric analysis and support an integrative relationship between the nasal septum and premaxilla. Thus, continued assessment of the growth and integration of the nasal septum and premaxilla is potentially informative regarding the complex developmental mechanisms that underlie facial reduction in genus Homo evolution. Anat Rec, 294:68-78, 2011. V V C 2010 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Holton

Franciscus

Marshall

et al. 2010

The Anatomical Record

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“…To further investigate the contribution of fibulin-5 to premaxillary bone development, we focused on the premaxillo-maxillary suture (PMMS) and nasal septal cartilage, both of which determine anterior facial growth [21,22,23,24,25,26]. At P0, fibulin-5 was localized in PMMS (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…As the nasal septum cartilage is involved in the lengthening of the anterior part of head [24,25,26], we investigated whether fibulin-5 is localized in septal cartilage. However, fibulin-5 did not exist in septal cartilage, suggesting it is not likely that the defect in premaxillary bone elongation seen in KO mice is due to shortened and/or malformed nasal cartilage.…”

Section: Discussionmentioning

confidence: 99%

Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice

Noda¹,

Nakamura

Komatsu

2015

Biochemical and Biophysical Research Communications

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Craniofacial sutures govern the shape of the craniofacial skeleton during postnatal development. The differentiation of suture mesenchymal cells to osteoblasts is precisely regulated in part by signaling through cell surface receptors that interact with extracellular proteins. Here we report that fibulin-5, a key extracellular matrix protein, is important for craniofacial skeletal development in mice. Fibulin-5 is deposited as a fibrous matrix in cranial neural crest-derived mesenchymal tissues, including craniofacial sutures. Fibulin-5-null mice show decreased premaxillary bone outgrowth during postnatal stages. While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative. Our study provides the first evidence that fibulin-5 is indispensable for the regulation of facial suture mesenchymal cell proliferation required for craniofacial skeletal morphogenesis.

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Otolaryngologic Plastic Surgery, 1961

Becker¹

1962

Archives of Otolaryngology - Head and Neck Surgery

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Rabbit Snout Gro+wth: Effect of Injury to Septovomeral Region

Cited by 60 publications

References 3 publications

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice

Otolaryngologic Plastic Surgery, 1961

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