2023
DOI: 10.3390/pathogens12091117
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Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario

Arlex Rodríguez-Durán,
Shafi Ullah,
Luís Fernando Parizi
et al.

Abstract: Studies evaluating candidate tick-derived proteins as anti-tick vaccines in natural hosts have been limited due to high costs. To overcome this problem, animal models are used in immunization tests. The aim of this article was to review the use of rabbits as an experimental model for the evaluation of tick-derived proteins as vaccines. A total of 57 tick proteins were tested for their immunogenic potential using rabbits as models for vaccination. The most commonly used rabbit breeds were New Zealand (73.8%), J… Show more

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Cited by 6 publications
(1 citation statement)
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“…Among these, Rhipicephalus sanguineus sensu lato ( R. sanguineus s.l.) has been used as a tick model in various vaccine experiments with rabbits as host [ 25 ]. Although some of these tick proteins have been shown to induce some degree of protection, none of them alone showed sufficient efficacy for the development of a commercial vaccine [ 26 ].…”
Section: Introductionmentioning
confidence: 99%
“…Among these, Rhipicephalus sanguineus sensu lato ( R. sanguineus s.l.) has been used as a tick model in various vaccine experiments with rabbits as host [ 25 ]. Although some of these tick proteins have been shown to induce some degree of protection, none of them alone showed sufficient efficacy for the development of a commercial vaccine [ 26 ].…”
Section: Introductionmentioning
confidence: 99%