Rabdomiólisis grave secundaria a deshidratación hipernatrémica

Mastro-Martínez, Ignacio; Montes-Arjona, A.M.; Escudero-Lirio, Margarita; Hernández-García, Bárbara; Padial, J Fernández-Cantalejo

doi:10.1016/j.rchipe.2015.06.016

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Hypernatremia means a plasma sodium concentration of more than 145 mmol/L 9 . The hypertonic state caused by hypernatremia also has a tremendous impact on the organism, and the deleterious effects of this hypertonic state on patients include brain cell shrinkage, cerebral demyelination, coma, rhabdomyolysis and reduced left ventricular function 10 and rhabdomyolysis 11,12 . The development of hypernatremia in COVID‐19 patients is usually due to fever, diarrhea, anorexia, and decreased fluid intake, 13 in addition, studies have shown that advanced age, dementia, and institutionalization are important risk factors for the development of hypernatremia in patients with COVID‐19 14 .…”

Section: Introductionmentioning

confidence: 99%

“… 9 The hypertonic state caused by hypernatremia also has a tremendous impact on the organism, and the deleterious effects of this hypertonic state on patients include brain cell shrinkage, cerebral demyelination, coma, rhabdomyolysis and reduced left ventricular function 10 and rhabdomyolysis. 11 , 12 The development of hypernatremia in COVID‐19 patients is usually due to fever, diarrhea, anorexia, and decreased fluid intake, 13 in addition, studies have shown that advanced age, dementia, and institutionalization are important risk factors for the development of hypernatremia in patients with COVID‐19. 14 Recent research indicates that the prevalence of hypernatremia in patients with COVID‐19 is between 2% and 7% and is associated with the risk of death in patients with COVID‐19, 6 , 7 , 8 , 15 , 16 this suggests that hypernatremia is associated with mortality risk in patients with COVID‐19.…”

Section: Introductionmentioning

confidence: 99%

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Association of hypernatremia with mortality in patients with COVID‐19: A systematic review and meta‐analysis

Ma,

Zhang,

Hou

2023

Immunity Inflam & Disease

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BackgroundThe COVID‐19 pandemic worldwide has caused varying degrees of severity of lung damage in patients, with acute respiratory distress and death in severe cases. However, this is not directly caused by the virus itself, but by the production of inflammasome by monocytes in the body, leading to a systemic inflammatory response, which results in a very poor clinical prognosis for patients with COVID‐19.ObjectiveThe purpose of this meta‐analysis was to look at the relationship between hypernatremia and mortality in COVID‐19 patients.MethodsWe searched the PubMed, Web of Science, Embase, and Cochrane databases for articles published from the inception of the database until August 27, 2022. Three researchers reviewed the literature, retrieved data, and assessed the quality of the literature, respectively. A meta‐analysis was performed using State 17 software to assess the value of the effect of hypernatremia on mortality in patients with new coronavirus pneumonia.ResultsA total of nine publications was finally included in this study, including a total of 11,801 patients with COVID‐19, including 1278 in the hypernatremia group and 10,523 in the normonatremia group. Meta‐analysis showed that hypernatremia was associated with mortality in patients with COVID‐19 [OR = 4.15, 95% CI (2.95–5.84), p = .002, I² = 66.7%] with a sensitivity of 0.36 [0.26, 0.48] and a specificity of 0.88 [0.83, 0.91]. The posterior probability of mortality was 42% in patients with COVID‐19 hypernatremia and 15% in patients who did not have COVID‐19 hypernatremia.ConclusionAccording to available data, hypernatremia is associated with death in patients with COVID‐19.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of hypernatremia with mortality in patients with COVID‐19: A systematic review and meta‐analysis

Ma,

Zhang,

Hou

2023

Immunity Inflam & Disease

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Hypothalamic hypernatremic myopathy: A single‐center case series

Bao

Liu

et al. 2023

Muscle and Nerve

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Introduction/Aims Hypernatremia myopathy is a rare disease often unrecognized by clinicians. This study aimed to present a case series of hypernatremic myopathy with an emphasis on profiling its clinical characteristics and exploring its pathogenesis. Methods We reviewed seven patients with hypernatremic myopathy and reported their demographic data, etiology, clinical manifestations, and laboratory and electrophysiological characteristics. A muscle biopsy was performed on one patient. Results All patients had hypothalamic lesions as the cause of the hypernatremia including craniopharyngioma, germinoma, pituitary adenoma, Langerhans cell histiocytosis, and glioma. The clinical manifestations varied from mild weakness to complete paralysis. Myalgia and muscle cramps were also observed. Four of the patients had rhabdomyolysis on admission and developed acute kidney injury. All patients had markedly elevated serum creatine kinase (CK) and sodium levels. There was a significant positive correlation between serum sodium and CK levels. A high prevalence of hypopituitarism in different axes was observed in our study. Central hypogonadism (5 of 7), central hypothyroidism (3 of 7), and central diabetes insipidus (3 of 7) were the most common manifestations of hypothalamic dysfunction. Myopathic changes were observed on needle electromyography. The muscle biopsy of one patient showed diffuse necrotic fibers and scattered hypercontracted fibers with increased ragged red fibers. Discussion Hypernatremia myopathy should be considered in hypernatremic patients with muscle weakness and myalgia. Rhabdomyolysis frequently occurs and may lead to acute kidney injury in hypernatremia myopathy. Testing of hormone levels and performance of brain magnetic resonance imaging for possible hypothalamic lesions is strongly recommended.

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Early ICU-acquired hypernatraemia is associated with injury severity and preceded by reduced renal sodium and chloride excretion in polytrauma patients

Rugg

Bachler

Mösenbacher

et al. 2021

Journal of Critical Care

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Rabdomiólisis grave secundaria a deshidratación hipernatrémica

Abstract: Severe hypernatraemia is described as a rare cause of rhabdomyolysis and renal failure. In critically ill patients, it is important to have a high index of suspicion for rhabdomyolysis and performing serial determinations of creatine phosphokinase for early detection and treatment.

Cited by 5 publications

References 16 publications

Association of hypernatremia with mortality in patients with COVID‐19: A systematic review and meta‐analysis

Association of hypernatremia with mortality in patients with COVID‐19: A systematic review and meta‐analysis

Hypothalamic hypernatremic myopathy: A single‐center case series

Early ICU-acquired hypernatraemia is associated with injury severity and preceded by reduced renal sodium and chloride excretion in polytrauma patients

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