Rabdomiosarcoma orbitario: dificultades en el Protocolo de Tratamiento Europeo

Pascual, N Olivier; Calvo, J. Peralta; Gómez, JM Abelairas

doi:10.4321/s0365-66912005000600006

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 – 26 Cassady et al 27 reported that high-dose RT decreases disease recurrence after orbital exenteration. In addition, Olivier Pascual et al 7 found that early RT and complete tumorectomy may be important for the treatment of orbital rhabdomyosarcoma. However, patients who undergo primary surgery suffer blindness, disfigurement, and pain, which significantly affects their quality of life.…”

Section: Discussionmentioning

confidence: 99%

The prognosis and effects of local treatment strategies for orbital embryonal rhabdomyosarcoma: a population-based study

Tang

Zhang

et al. 2018

CMAR

View full text Add to dashboard Cite

IntroductionOrbital embryonal rhabdomyosarcoma is a rare childhood malignancy with a good prognosis, but the optimal treatment remains unclear. Using a population-based cancer registry, we assessed the prognoses and survival outcomes of patients with orbital embryonal rhabdomyosarcoma according to the local treatment strategy.Patients and methodsPatients diagnosed with orbital embryonal rhabdomyosarcoma between 1988 and 2012 as part of the Surveillance Epidemiology and End Results program were included. Univariate and multivariate Cox regression analyses were performed to determine the prognostic factors associated with cause-specific survival (CSS) and overall survival (OS).ResultsIn total, 102 patients were included; their median age was 6 years, 78.4% were white, and 56.9% were male. The median tumor size was 30 mm. Of 20 patients with an available histologic grade, the tumors of 90% were poorly differentiated/undifferentiated. Of 92 patients with available surgical and radiotherapy (RT) statuses, 50 (54.3%), 36 (39.1%), and 6 (6.5%) received surgery and RT, primary RT, and primary surgery, respectively. Ninety-five patients (93.1%) received chemotherapy. The 5- and 10-year CSSs of the entire cohort were 94.3% and 92.2%, respectively. The 5- and 10-year OSs were 93.3% and 91.3%, respectively. In 95 patients who were followed up for at least 12 months, there were no significant prognostic factors related to CSS and OS. Furthermore, the local treatment strategy did not significantly affect CSS (P=0.29) or OS (P=0.468).ConclusionThere is no local treatment of choice for orbital embryonal rhabdomyosarcoma in terms of survival. However, RT is a reasonable alternative treatment to surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

The prognosis and effects of local treatment strategies for orbital embryonal rhabdomyosarcoma: a population-based study

Tang

Zhang

et al. 2018

CMAR

View full text Add to dashboard Cite

show abstract

Orbital rhabdomyosarcomas: A review

Jurdy

Merks

Pieters

et al. 2013

Saudi Journal of Ophthalmology

View full text Add to dashboard Cite

Rhabdomyosarcoma (RMS) is a highly malignant tumor and is one of the few life-threatening diseases that present first to the ophthalmologist. It is the most common soft-tissue sarcoma of the head and neck in childhood with 10% of all cases occurring in the orbit. RMS has been reported from birth to the seventh decade, with the majority of cases presenting in early childhood. Survival has changed drastically over the years, from 30% in the 1960's to 90% presently, with the advent of new diagnostic and therapeutic modalities. The purpose of this review is to provide a general overview of primary orbital RMS derived from a literature search of material published over the last 10 years, as well as to present two representative cases of patients that have been managed at our institute.

show abstract

Primary orbital and adnexal rhabdomyosarcoma: a study of 54 Asian Indian patients

Agarwal,

Vempuluru,

Mohammad

et al. 2024

Orbit

View full text Add to dashboard Cite

Rabdomiosarcoma orbitario: dificultades en el Protocolo de Tratamiento Europeo

Abstract: Management of orbital rhabdomyosarcoma following the European Protocol leads to poor results compared with the American protocol. Early radiotherapy and complete tumoral excision could play a role in management of this tumour

Cited by 4 publications

References 0 publications

The prognosis and effects of local treatment strategies for orbital embryonal rhabdomyosarcoma: a population-based study

The prognosis and effects of local treatment strategies for orbital embryonal rhabdomyosarcoma: a population-based study

Orbital rhabdomyosarcomas: A review

Primary orbital and adnexal rhabdomyosarcoma: a study of 54 Asian Indian patients

Contact Info

Product

Resources

About